| 9/18/2021 | Harvard | 44 | at | Georgetown (2-8) | 9 | at Pat | ||
| 9/24/2021 | Brown (2-8,1-6) | 17 | at | Harvard | 49 | |||
| 10/2/2021 | Harvard | 38 | at | Holy Cross (10-3) | 13 | at Pat | ||
| 10/9/2021 | Cornell (2-8,1-6) | 10 | at | Harvard | 24 | |||
| 10/16/2021 | Lafayette (3-8) | 3 | at | Harvard | 30 | Pat | ||
| 10/23/2021 | Harvard | 16 | at | Princeton (9-1,6-1) | 18 | 5OT | ||
| 10/30/2021 | Dartmouth (9-1,6-1) | 20 | at | Harvard | 17 | |||
| 11/6/2021 | Harvard | 49 | at | Columbia (7-3,4-3) | 21 | |||
| 11/13/2021 | Pennsylvania (3-7,1-6) | 7 | at | Harvard | 23 | |||
| 11/20/2021 | Harvard | 34 | at | Yale (5-5,4-3) | 31 |
| vs Harvard | vs Other Opponents | Harvard compared to OOs | |
| Record: | 2-8 | 50-44 | |
| Points Scored: | 14.90 | 26.80 | 11.90 |
| Points Allowed: | 32.40 | 23.43 | 8.97 |
| Margin: | -17.50 | 3.37 | 20.87 |
| Total Points: | 47.30 | 50.23 | -2.93 |