| 9/2/2021 | Wagner | 7 | at | Buffalo (4-8) | 69 | at MAC | ||
| 9/11/2021 | Central Conn (4-7,4-3) | 21 | at | Wagner | 19 | |||
| 9/18/2021 | Wagner | 24 | at | St Francis PA (5-6,4-3) | 39 | |||
| 9/25/2021 | Wagner | 7 | at | Temple (3-9) | 41 | at AAC | ||
| 10/2/2021 | Delaware State (5-6) | 33 | at | Wagner | 27 | OT | MEAC | |
| 10/9/2021 | Wagner | 7 | at | Fordham (6-5) | 56 | at Pat | ||
| 10/23/2021 | Bryant (7-4,5-2) | 31 | at | Wagner | 10 | |||
| 10/30/2021 | Wagner | 14 | at | LIU (2-8,2-5) | 28 | |||
| 11/6/2021 | Merrimack (5-6,2-5) | 35 | at | Wagner | 26 | |||
| 11/13/2021 | Wagner | 0 | at | Sacred Heart (8-4,6-1) | 27 | |||
| 11/20/2021 | Duquesne (7-3,5-2) | 44 | at | Wagner | 0 |
| vs Wagner | vs Other Opponents | Wagner compared to OOs | |
| Record: | 11-0 | 45-66 | |
| Points Scored: | 38.55 | 22.88 | -15.67 |
| Points Allowed: | 12.82 | 28.81 | -15.99 |
| Margin: | 25.73 | -5.93 | -31.66 |
| Total Points: | 51.37 | 51.69 | -0.32 |