| 9/4/2021 | Towson (4-7) | 31 | at | Morgan State | 0 | CAAF | ||
| 9/11/2021 | Morgan State | 20 | at | Tulane (2-10) | 69 | at AAC | ||
| 9/18/2021 | Morgan State | 7 | at | Sacred Heart (8-4) | 21 | at NE | ||
| 10/2/2021 | St Francis PA (5-6) | 27 | at | Morgan State | 14 | NE | ||
| 10/8/2021 | Morgan State | 0 | at | Howard (3-8,1-4) | 27 | |||
| 10/16/2021 | Morgan State | 14 | at | South Carolina State (7-5,5-0) | 37 | |||
| 10/23/2021 | North Carolina Central (6-5,4-1) | 28 | at | Morgan State | 17 | |||
| 10/30/2021 | Morgan State | 20 | at | Norfolk State (6-5,2-3) | 31 | |||
| 11/4/2021 | Delaware State (5-6,2-3) | 14 | at | Morgan State | 20 | |||
| 11/13/2021 | Morgan State | 14 | at | Albany NY (2-9) | 41 | at CAAF | ||
| 11/20/2021 | Georgetown (2-8) | 21 | at | Morgan State | 28 | Pat |
| vs Morgan State | vs Other Opponents | Morgan State compared to OOs | |
| Record: | 9-2 | 41-71 | |
| Points Scored: | 31.55 | 22.63 | -8.92 |
| Points Allowed: | 14.00 | 27.54 | -13.54 |
| Margin: | 17.55 | -4.91 | -22.46 |
| Total Points: | 45.55 | 50.17 | -4.62 |