| 8/28/2021 | Nebraska | 22 | at | Illinois (5-7,4-5) | 30 | |||
| 9/4/2021 | Fordham (6-5) | 7 | at | Nebraska | 52 | Pat (1AA) | ||
| 9/11/2021 | Buffalo (4-8) | 3 | at | Nebraska | 28 | MAC | ||
| 9/18/2021 | Nebraska | 16 | at | Oklahoma (11-2) | 23 | at B12 | ||
| 9/25/2021 | Nebraska | 20 | at | Michigan State (11-2,7-2) | 23 | OT | ||
| 10/2/2021 | Northwestern (3-9,1-8) | 7 | at | Nebraska | 56 | |||
| 10/9/2021 | Michigan (12-2,9-1) | 32 | at | Nebraska | 29 | |||
| 10/16/2021 | Nebraska | 23 | at | Minnesota (9-4,6-3) | 30 | |||
| 10/30/2021 | Purdue (9-4,6-3) | 28 | at | Nebraska | 23 | |||
| 11/6/2021 | Ohio State (11-2,8-1) | 26 | at | Nebraska | 17 | |||
| 11/20/2021 | Nebraska | 28 | at | Wisconsin (9-4,6-3) | 35 | |||
| 11/26/2021 | Iowa (10-4,7-3) | 28 | at | Nebraska | 21 |
| vs Nebraska | vs Other Opponents | Nebraska compared to OOs | |
| Record: | 9-3 | 91-50 | |
| Points Scored: | 22.67 | 30.31 | 7.64 |
| Points Allowed: | 27.92 | 22.58 | 5.34 |
| Margin: | -5.25 | 7.73 | 12.98 |
| Total Points: | 50.59 | 52.89 | -2.30 |