| 9/2/2021 | Wagner | 7 | at | Buffalo | 69 | @ MAC (1A) | ||
| LIU | 10 | at | Florida Intl | 48 | @ CUSA (1A) | |||
| 9/3/2021 | Southern Connecticut | 28 | at | Central Conn | 21 | NE10 (D2) | ||
| St Francis PA | 15 | at | Eastern Michigan | 35 | @ MAC (1A) | |||
| 9/4/2021 | Saint Anselm | 23 | at | Merrimack | 55 | NE10 (D2) | ||
| Bryant | 21 | at | Rhode Island | 45 | @ CAAF | |||
| Bucknell | 0 | at | Sacred Heart | 21 | Pat | |||
| Duquesne | 3 | at | TCU | 45 | @ B12 (1A) | |||
| 9/11/2021 | Sacred Heart | 6 | at | Bryant | 17 | |||
| St Francis PA | 10 | at | Delaware | 27 | @ CAAF | |||
| Merrimack | 35 | at | Holy Cross | 21 | @ Pat | |||
| Duquesne | 28 | at | Ohio | 26 | @ MAC (1A) | |||
| Central Conn | 21 | at | Wagner | 19 | ||||
| LIU | 0 | at | West Virginia | 66 | @ B12 (1A) | |||
| 9/18/2021 | Bryant | 14 | at | Akron | 35 | @ MAC (1A) | ||
| Southeastern Louisiana | 56 | at | Central Conn | 10 | SLC | |||
| Merrimack | 26 | at | Maine | 31 | @ CAAF | |||
| LIU | 7 | at | Miami-Ohio | 42 | @ MAC (1A) | |||
| Morgan State | 7 | at | Sacred Heart | 21 | MEAC | |||
| Wagner | 24 | at | St Francis PA | 39 | ||||
| 9/25/2021 | Sacred Heart | 3 | at | Dartmouth | 41 | @ Ivy | ||
| Merrimack | 47 | at | Delaware State | 10 | @ MEAC | |||
| Virginia U-Lynchburg | 7 | at | Duquesne | 56 | None (Unk?) | |||
| Bryant | 34 | at | Marist | 17 | @ Pio | |||
| Central Conn | 0 | at | Miami-Florida | 69 | @ ACC (1A) | |||
| Norfolk State | 28 | at | St Francis PA | 16 | MEAC | |||
| Wagner | 7 | at | Temple | 41 | @ AAC (1A) | |||
| 10/2/2021 | Brown | 29 | at | Bryant | 36 | Ivy | ||
| Sacred Heart | 17 | at | Howard | 22 | @ MEAC | |||
| Duquesne | 37 | at | Merrimack | 14 | ||||
| St Francis PA | 27 | at | Morgan State | 14 | @ MEAC | |||
| Delaware State | 33 | at | Wagner | 27 | OT | MEAC | ||
| 10/9/2021 | Columbia | 22 | at | Central Conn | 20 | Ivy | ||
| Bryant | 34 | at | Duquesne | 39 | ||||
| Wagner | 7 | at | Fordham | 56 | @ Pat | |||
| Merrimack | 10 | at | Sacred Heart | 20 | ||||
| LIU | 10 | at | St Francis PA | 55 | ||||
| 10/16/2021 | St Francis PA | 17 | at | Bryant | 18 | |||
| Merrimack | 43 | at | LIU | 5 | ||||
| Central Conn | 17 | at | Sacred Heart | 27 | ||||
| 10/23/2021 | LIU | 30 | at | Central Conn | 13 | |||
| Duquesne | 13 | at | Sacred Heart | 31 | ||||
| Bryant | 31 | at | Wagner | 10 | ||||
| 10/30/2021 | St Francis PA | 17 | at | Duquesne | 10 | |||
| Wagner | 14 | at | LIU | 28 | ||||
| Central Conn | 49 | at | Merrimack | 21 | ||||
| 11/6/2021 | Bryant | 15 | at | Central Conn | 30 | |||
| Duquesne | 34 | at | LIU | 28 | ||||
| Sacred Heart | 14 | at | St Francis PA | 13 | ||||
| Merrimack | 35 | at | Wagner | 26 | ||||
| 11/13/2021 | LIU | 7 | at | Bryant | 52 | |||
| Central Conn | 27 | at | Duquesne | 31 | ||||
| Wagner | 0 | at | Sacred Heart | 27 | ||||
| Merrimack | 6 | at | St Francis PA | 22 | ||||
| 11/20/2021 | St Francis PA | 21 | at | Central Conn | 24 | |||
| Sacred Heart | 38 | at | LIU | 14 | ||||
| Bryant | 58 | at | Merrimack | 14 | ||||
| Duquesne | 44 | at | Wagner | 0 | ||||
| 11/27/2021 | Sacred Heart | 10 | at | Holy Cross | 13 | @ Pat |