| 9/4/2021 | Temple | 14 | at | Rutgers (5-8) | 61 | at B10 | ||
| 9/11/2021 | Temple | 45 | at | Akron (2-10) | 24 | at MAC | ||
| 9/18/2021 | Boston College (6-6) | 28 | at | Temple | 3 | ACC | ||
| 9/25/2021 | Wagner (0-11) | 7 | at | Temple | 41 | NE (1AA) | ||
| 10/2/2021 | Memphis (6-6,3-5) | 31 | at | Temple | 34 | |||
| 10/8/2021 | Temple | 3 | at | Cincinnati (13-1,9-0) | 52 | |||
| 10/23/2021 | Temple | 14 | at | South Florida (2-10,1-7) | 34 | |||
| 10/30/2021 | UCF (9-4,5-3) | 49 | at | Temple | 7 | |||
| 11/6/2021 | Temple | 3 | at | East Carolina (7-5,5-3) | 45 | |||
| 11/13/2021 | Houston (12-2,8-1) | 37 | at | Temple | 8 | |||
| 11/20/2021 | Temple | 10 | at | Tulsa (7-6,5-3) | 44 | |||
| 11/27/2021 | Navy (4-8,3-5) | 38 | at | Temple | 14 |
| vs Temple | vs Other Opponents | Temple compared to OOs | |
| Record: | 9-3 | 64-74 | |
| Points Scored: | 37.50 | 25.31 | -12.19 |
| Points Allowed: | 16.33 | 28.33 | -12.00 |
| Margin: | 21.17 | -3.02 | -24.19 |
| Total Points: | 53.83 | 53.64 | 0.19 |