| 9/4/2021 | West Virginia | 24 | at | Maryland (7-6) | 30 | at B10 | ||
| 9/11/2021 | LIU (2-8) | 0 | at | West Virginia | 66 | NE (1AA) | ||
| 9/18/2021 | Virginia Tech (6-7) | 21 | at | West Virginia | 27 | ACC | ||
| 9/25/2021 | West Virginia | 13 | at | Oklahoma (11-2,7-2) | 16 | |||
| 10/2/2021 | Texas Tech (7-6,3-6) | 23 | at | West Virginia | 20 | |||
| 10/9/2021 | West Virginia | 20 | at | Baylor (12-2,8-2) | 45 | |||
| 10/23/2021 | West Virginia | 29 | at | TCU (5-7,3-6) | 17 | |||
| 10/30/2021 | Iowa State (7-6,5-4) | 31 | at | West Virginia | 38 | |||
| 11/6/2021 | Oklahoma State (12-2,8-2) | 24 | at | West Virginia | 3 | |||
| 11/13/2021 | West Virginia | 17 | at | Kansas State (8-5,4-5) | 34 | |||
| 11/20/2021 | Texas (5-7,3-6) | 23 | at | West Virginia | 31 | |||
| 11/27/2021 | West Virginia | 34 | at | Kansas (2-10,1-8) | 28 | |||
| 12/28/2021 | West Virginia | 6 | vs | Minnesota (9-4) | 18 | Guaranteed Rate Bowl - Phoenix AZ | vs B10 |
| vs West Virginia | vs Other Opponents | West Virginia compared to OOs | |
| Record: | 7-6 | 86-66 | |
| Points Scored: | 23.85 | 29.01 | 5.16 |
| Points Allowed: | 25.23 | 27.00 | -1.77 |
| Margin: | -1.38 | 2.01 | 3.39 |
| Total Points: | 49.08 | 56.01 | -6.93 |