| 9/4/2021 | Southeastern Louisiana | 49 | at | North Alabama (3-8) | 28 | at BigS | ||
| 9/11/2021 | Southeastern Louisiana | 42 | at | Louisiana Tech (3-9) | 45 | at CUSA | ||
| 9/18/2021 | Southeastern Louisiana | 56 | at | Central Conn (4-7) | 10 | at NE | ||
| 10/2/2021 | Southeastern Louisiana | 38 | at | McNeese State (4-7,3-5) | 35 | |||
| 10/9/2021 | Southeastern Louisiana | 58 | at | Nicholls State (6-5,5-3) | 48 | |||
| 10/16/2021 | Houston Baptist (0-11,0-8) | 24 | at | Southeastern Louisiana | 61 | |||
| 10/23/2021 | Southeastern Louisiana | 51 | at | Northwestern State (3-8,3-5) | 14 | |||
| 10/30/2021 | McNeese State (4-7,3-5) | 20 | at | Southeastern Louisiana | 23 | |||
| 11/6/2021 | Southeastern Louisiana | 52 | at | Incarnate Word (10-3,7-1) | 55 | |||
| 11/13/2021 | Northwestern State (3-8,3-5) | 28 | at | Southeastern Louisiana | 56 | |||
| 11/18/2021 | Nicholls State (6-5,5-3) | 45 | at | Southeastern Louisiana | 42 | |||
| 11/27/2021 | Florida A&M (9-3) | 14 | at | Southeastern Louisiana | 38 | SWAC | ||
| 12/4/2021 | Southeastern Louisiana | 20 | at | James Madison (12-2) | 59 | at CAAF |
| vs Southeastern Louisiana | vs Other Opponents | Southeastern Louisiana compared to OOs | |
| Record: | 4-9 | 62-69 | |
| Points Scored: | 32.69 | 28.46 | -4.23 |
| Points Allowed: | 45.08 | 28.20 | 16.88 |
| Margin: | -12.39 | 0.26 | 12.65 |
| Total Points: | 77.77 | 56.66 | 21.11 |