| 9/2/2021 | LIU (2-8) | 10 | at | Florida Intl | 48 | NE (1AA) | ||
| 9/11/2021 | Texas State (4-8) | 23 | at | Florida Intl | 17 | OT | SBC | |
| 9/18/2021 | Florida Intl | 21 | at | Texas Tech (7-6) | 54 | at B12 | ||
| 9/25/2021 | Florida Intl | 27 | at | Central Michigan (9-4) | 31 | at MAC | ||
| 10/2/2021 | Florida Intl | 21 | at | Florida Atlantic (5-7,3-5) | 58 | |||
| 10/8/2021 | UNC-Charlotte (5-7,3-5) | 45 | at | Florida Intl | 33 | |||
| 10/23/2021 | Western Kentucky (9-5,7-2) | 34 | at | Florida Intl | 19 | |||
| 10/30/2021 | Florida Intl | 0 | at | Marshall (7-6,5-3) | 38 | |||
| 11/6/2021 | Old Dominion (6-7,5-3) | 47 | at | Florida Intl | 24 | |||
| 11/13/2021 | Florida Intl | 10 | at | Middle Tenn State (7-6,4-4) | 50 | |||
| 11/20/2021 | North Texas (6-7,5-3) | 49 | at | Florida Intl | 7 | |||
| 11/27/2021 | Florida Intl | 17 | at | Southern Miss (3-9,2-6) | 37 |
| vs Florida Intl | vs Other Opponents | Florida Intl compared to OOs | |
| Record: | 11-1 | 59-79 | |
| Points Scored: | 39.67 | 27.17 | -12.50 |
| Points Allowed: | 20.33 | 29.77 | -9.44 |
| Margin: | 19.34 | -2.60 | -21.94 |
| Total Points: | 60.00 | 56.94 | 3.06 |