| 8/28/2021 | Alcorn State | 14 | vs | North Carolina Central | 23 | Atlanta GA | vs SWAC | |
| 9/4/2021 | South Carolina State | 41 | at | Alabama A&M | 42 | @ SWAC | ||
| Bowie State | 24 | at | Delaware State | 32 | CIAA (D2) | |||
| Towson | 31 | at | Morgan State | 0 | CAAF | |||
| Howard | 14 | at | Richmond | 38 | @ CAAF | |||
| Norfolk State | 10 | at | Toledo | 49 | @ MAC (1A) | |||
| 9/11/2021 | South Carolina State | 3 | at | Clemson | 49 | @ ACC (1A) | ||
| Georgetown | 20 | at | Delaware State | 14 | OT | Pat | ||
| North Carolina Central | 10 | at | Marshall | 44 | @ CUSA (1A) | |||
| Howard | 0 | at | Maryland | 62 | @ B10 (1A) | |||
| Morgan State | 20 | at | Tulane | 69 | @ AAC (1A) | |||
| Norfolk State | 16 | at | Wake Forest | 41 | @ ACC (1A) | |||
| 9/18/2021 | Delaware State | 6 | at | East Tennessee St | 38 | @ SoCon | ||
| Hampton | 48 | at | Howard | 32 | BigS | |||
| South Carolina State | 35 | at | New Mexico State | 43 | @ Ind (1A) | |||
| Elizabeth City State | 26 | at | Norfolk State | 63 | CIAA (D2) | |||
| Winston-Salem State | 13 | at | North Carolina Central | 20 | CIAA (D2) | |||
| Morgan State | 7 | at | Sacred Heart | 21 | @ NE | |||
| 9/25/2021 | Merrimack | 47 | at | Delaware State | 10 | NE | ||
| North Carolina Central | 14 | at | North Carolina A&T | 37 | @ BigS | |||
| Howard | 16 | at | Robert Morris | 22 | @ BigS | |||
| Norfolk State | 28 | at | St Francis PA | 16 | @ NE | |||
| 10/2/2021 | Norfolk State | 47 | at | Hampton | 44 | OT | @ BigS | |
| Sacred Heart | 17 | at | Howard | 22 | NE | |||
| North Carolina Central | 16 | at | Mississippi Valley State | 17 | @ SWAC | |||
| St Francis PA | 27 | at | Morgan State | 14 | NE | |||
| Bethune-Cookman | 35 | at | South Carolina State | 42 | SWAC | |||
| Delaware State | 33 | at | Wagner | 27 | OT | @ NE | ||
| 10/8/2021 | Morgan State | 0 | at | Howard | 27 | |||
| 10/9/2021 | Virginia U-Lynchburg | 6 | at | Delaware State | 56 | None (Unk?) | ||
| South Carolina State | 7 | at | Florida A&M | 30 | @ SWAC | |||
| Tennessee Tech | 27 | at | North Carolina Central | 16 | OVC | |||
| 10/16/2021 | Virginia U-Lynchburg | 14 | at | Norfolk State | 42 | None (Unk?) | ||
| Morgan State | 14 | at | South Carolina State | 37 | ||||
| 10/23/2021 | South Carolina State | 13 | at | Delaware State | 7 | |||
| Norfolk State | 45 | at | Howard | 31 | ||||
| North Carolina Central | 28 | at | Morgan State | 17 | ||||
| 10/30/2021 | Howard | 23 | at | Delaware State | 30 | |||
| Morgan State | 20 | at | Norfolk State | 31 | ||||
| South Carolina State | 27 | at | North Carolina Central | 24 | ||||
| 11/4/2021 | Delaware State | 14 | at | Morgan State | 20 | |||
| 11/6/2021 | Norfolk State | 36 | at | North Carolina Central | 38 | 2OT | ||
| Howard | 12 | at | South Carolina State | 15 | ||||
| 11/13/2021 | Morgan State | 14 | at | Albany NY | 41 | @ CAAF | ||
| Norfolk State | 26 | at | Delaware State | 28 | ||||
| North Carolina Central | 45 | at | Howard | 27 | ||||
| North Carolina A&T | 27 | at | South Carolina State | 17 | BigS | |||
| 11/20/2021 | Virginia U-Lynchburg | 6 | at | Howard | 56 | Suspended in 1st half | None (Unk?) | |
| Georgetown | 21 | at | Morgan State | 28 | Pat | |||
| South Carolina State | 31 | at | Norfolk State | 21 | ||||
| Delaware State | 28 | at | North Carolina Central | 34 | OT | |||
| 12/18/2021 | South Carolina State | 31 | vs | Jackson State | 10 | Celebration Bowl - Atlanta GA | vs SWAC |