| 9/4/2021 | Marist (5-5) | vs | Georgetown | Canceled COVID | Pio | |||
| 9/11/2021 | Georgetown | 20 | at | Delaware State (5-6) | 14 | OT | at MEAC | |
| 9/18/2021 | Harvard (8-2) | 44 | at | Georgetown | 9 | Ivy | ||
| 9/25/2021 | Georgetown | 24 | at | Columbia (7-3) | 35 | at Ivy | ||
| 10/2/2021 | Colgate (5-6,5-1) | 28 | at | Georgetown | 21 | |||
| 10/16/2021 | Georgetown | 14 | at | Holy Cross (10-3,6-0) | 48 | |||
| 10/23/2021 | Georgetown | 29 | at | Bucknell (1-10,0-6) | 21 | |||
| 10/30/2021 | Lafayette (3-8,2-4) | 24 | at | Georgetown | 23 | |||
| 11/6/2021 | Fordham (6-5,4-2) | 41 | at | Georgetown | 20 | |||
| 11/13/2021 | Georgetown | 9 | at | Lehigh (3-8,3-3) | 23 | |||
| 11/20/2021 | Georgetown | 21 | at | Morgan State (2-9) | 28 | at MEAC |
| vs Georgetown | vs Other Opponents | Georgetown compared to OOs | |
| Record: | 8-2 | 47-63 | |
| Points Scored: | 30.60 | 21.06 | -9.54 |
| Points Allowed: | 19.00 | 26.15 | -7.15 |
| Margin: | 11.60 | -5.09 | -16.69 |
| Total Points: | 49.60 | 47.21 | 2.39 |