| 9/4/2021 | West Virginia (6-7) | 24 | at | Maryland | 30 | B12 | ||
| 9/11/2021 | Howard (3-8) | 0 | at | Maryland | 62 | MEAC (1AA) | ||
| 9/17/2021 | Maryland | 20 | at | Illinois (5-7,4-5) | 17 | |||
| 9/25/2021 | Kent State (7-7) | 16 | at | Maryland | 37 | MAC | ||
| 10/1/2021 | Iowa (10-4,7-3) | 51 | at | Maryland | 14 | |||
| 10/9/2021 | Maryland | 17 | at | Ohio State (11-2,8-1) | 66 | |||
| 10/23/2021 | Maryland | 16 | at | Minnesota (9-4,6-3) | 34 | |||
| 10/30/2021 | Indiana (2-10,0-9) | 35 | at | Maryland | 38 | |||
| 11/6/2021 | Penn State (7-6,4-5) | 31 | at | Maryland | 14 | |||
| 11/13/2021 | Maryland | 21 | at | Michigan State (11-2,7-2) | 40 | |||
| 11/20/2021 | Michigan (12-2,9-1) | 59 | at | Maryland | 18 | |||
| 11/27/2021 | Maryland | 40 | at | Rutgers (5-8,2-7) | 16 | |||
| 12/29/2021 | Maryland | 54 | vs | Virginia Tech (6-7) | 10 | Pinstribe Bowl - Bronx NY | vs ACC |
| vs Maryland | vs Other Opponents | Maryland compared to OOs | |
| Record: | 6-7 | 88-67 | |
| Points Scored: | 30.69 | 26.82 | -3.87 |
| Points Allowed: | 29.31 | 23.72 | 5.59 |
| Margin: | 1.38 | 3.10 | 1.72 |
| Total Points: | 60.00 | 50.54 | 9.46 |