| 9/4/2021 | Marshall | 49 | at | Navy (4-8) | 7 | at AAC | ||
| 9/11/2021 | North Carolina Central (6-5) | 10 | at | Marshall | 44 | MEAC (1AA) | ||
| 9/18/2021 | East Carolina (7-5) | 42 | at | Marshall | 38 | AAC | ||
| 9/23/2021 | Marshall | 30 | at | Appalachian State (10-4) | 31 | at SBC | ||
| 10/2/2021 | Marshall | 28 | at | Middle Tenn State (7-6,4-4) | 34 | |||
| 10/9/2021 | Old Dominion (6-7,5-3) | 13 | at | Marshall | 20 | OT | ||
| 10/15/2021 | Marshall | 49 | at | North Texas (6-7,5-3) | 21 | |||
| 10/30/2021 | Florida Intl (1-11,0-8) | 0 | at | Marshall | 38 | |||
| 11/6/2021 | Marshall | 28 | at | Florida Atlantic (5-7,3-5) | 13 | |||
| 11/13/2021 | UAB (9-4,6-2) | 21 | at | Marshall | 14 | |||
| 11/20/2021 | Marshall | 49 | at | UNC-Charlotte (5-7,3-5) | 28 | |||
| 11/27/2021 | Western Kentucky (9-5,7-2) | 53 | at | Marshall | 21 | |||
| 12/18/2021 | UL Lafayette (13-1) | 36 | vs | Marshall | 21 | New Orleans Bowl - New Orleans LA | SBC |
| vs Marshall | vs Other Opponents | Marshall compared to OOs | |
| Record: | 6-7 | 82-70 | |
| Points Scored: | 23.77 | 29.32 | 5.55 |
| Points Allowed: | 33.00 | 26.57 | 6.43 |
| Margin: | -9.23 | 2.75 | 11.98 |
| Total Points: | 56.77 | 55.89 | 0.88 |