| 9/5/2021 | Jackson State | 7 | vs | Florida A&M (9-3,7-1) | 6 | Miami Gardens FL | ||
| 9/11/2021 | Tennessee State (5-6) | 16 | vs | Jackson State | 38 | Memphis TN | OVC | |
| 9/18/2021 | Jackson State | 7 | at | UL Monroe (4-8) | 12 | at SBC | ||
| 9/25/2021 | Delta State (5-6) | 17 | at | Jackson State | 24 | GSC (D2) | ||
| 10/9/2021 | Jackson State | 61 | at | Alabama A&M (7-3,5-3) | 15 | |||
| 10/16/2021 | Alabama State (5-6,3-5) | 7 | at | Jackson State | 28 | |||
| 10/23/2021 | Bethune-Cookman (2-9,2-6) | 12 | at | Jackson State | 42 | |||
| 10/30/2021 | Jackson State | 28 | at | Mississippi Valley State (4-7,3-5) | 19 | |||
| 11/6/2021 | Texas Southern (3-8,2-6) | 21 | at | Jackson State | 41 | |||
| 11/13/2021 | Jackson State | 21 | at | Southern (4-7,3-5) | 17 | |||
| 11/20/2021 | Alcorn State (6-5,5-3) | 10 | at | Jackson State | 24 | |||
| 12/4/2021 | Prairie View (7-5,6-3) | 10 | at | Jackson State | 27 | SWAC Championship | ||
| 12/18/2021 | South Carolina State (7-5) | 31 | vs | Jackson State | 10 | Celebration Bowl - Atlanta GA | MEAC |
| vs Jackson State | vs Other Opponents | Jackson State compared to OOs | |
| Record: | 2-11 | 66-67 | |
| Points Scored: | 14.85 | 26.58 | 11.73 |
| Points Allowed: | 27.54 | 29.44 | -1.90 |
| Margin: | -12.69 | -2.86 | 9.83 |
| Total Points: | 42.39 | 56.02 | -13.63 |