| 8/28/2021 | Alcorn State | 14 | vs | North Carolina Central (6-5) | 23 | Atlanta GA | vs MEAC | |
| 9/11/2021 | Northwestern State (3-8) | 10 | at | Alcorn State | 13 | SLC | ||
| 9/18/2021 | Alcorn State | 21 | at | South Alabama (5-7) | 28 | at SBC | ||
| 9/23/2021 | Alcorn State | 39 | at | Ark Pine Bluff (2-9,1-7) | 38 | |||
| 10/9/2021 | Grambling (4-7,3-5) | 20 | at | Alcorn State | 24 | |||
| 10/16/2021 | Alcorn State | 24 | at | Mississippi Valley State (4-7,3-5) | 12 | |||
| 10/23/2021 | Alcorn State | 44 | at | Texas Southern (3-8,2-6) | 27 | |||
| 10/30/2021 | Alcorn State | 35 | at | Southern (4-7,3-5) | 38 | |||
| 11/6/2021 | Alcorn State | 31 | at | Bethune-Cookman (2-9,2-6) | 35 | |||
| 11/13/2021 | Prairie View (7-5,6-3) | 29 | at | Alcorn State | 31 | |||
| 11/20/2021 | Alcorn State | 10 | at | Jackson State (11-2,9-0) | 24 |
| vs Alcorn State | vs Other Opponents | Alcorn State compared to OOs | |
| Record: | 5-6 | 46-68 | |
| Points Scored: | 25.82 | 23.70 | -2.12 |
| Points Allowed: | 26.00 | 29.75 | -3.75 |
| Margin: | -0.18 | -6.05 | -5.87 |
| Total Points: | 51.82 | 53.45 | -1.63 |