| 9/5/2021 | Jackson State (11-2,9-0) | 7 | vs | Florida A&M | 6 | Miami Gardens FL | ||
| 9/11/2021 | Fort Valley State (5-5) | 7 | at | Florida A&M | 34 | SIAC (D2) | ||
| 9/18/2021 | Florida A&M | 17 | at | South Florida (2-10) | 38 | at AAC | ||
| 10/2/2021 | Alabama State (5-6,3-5) | 0 | at | Florida A&M | 28 | |||
| 10/9/2021 | South Carolina State (7-5) | 7 | at | Florida A&M | 30 | MEAC | ||
| 10/16/2021 | Florida A&M | 35 | at | Alabama A&M (7-3,5-3) | 31 | |||
| 10/23/2021 | Florida A&M | 31 | at | Mississippi Valley State (4-7,3-5) | 28 | |||
| 10/30/2021 | Grambling (4-7,3-5) | 3 | at | Florida A&M | 26 | |||
| 11/6/2021 | Florida A&M | 29 | at | Southern (4-7,3-5) | 17 | |||
| 11/13/2021 | Florida A&M | 37 | at | Ark Pine Bluff (2-9,1-7) | 7 | |||
| 11/20/2021 | Bethune-Cookman (2-9,2-6) | 21 | vs | Florida A&M | 46 | Orlando FL | ||
| 11/27/2021 | Florida A&M | 14 | at | Southeastern Louisiana (9-4) | 38 | at SLC |
| vs Florida A&M | vs Other Opponents | Florida A&M compared to OOs | |
| Record: | 3-9 | 59-65 | |
| Points Scored: | 17.00 | 26.97 | 9.97 |
| Points Allowed: | 27.75 | 29.98 | -2.23 |
| Margin: | -10.75 | -3.01 | 7.74 |
| Total Points: | 44.75 | 56.95 | -12.20 |