| 9/4/2021 | Virginia Union (6-4) | 28 | at | Hampton | 42 | CIAA (D2) | ||
| 9/11/2021 | Hampton | 7 | at | Old Dominion (6-7) | 47 | at CUSA | ||
| 9/18/2021 | Hampton | 48 | at | Howard (3-8) | 32 | at MEAC | ||
| 10/2/2021 | Norfolk State (6-5) | 47 | at | Hampton | 44 | OT | MEAC | |
| 10/9/2021 | Kennesaw St (11-2,7-0) | 34 | at | Hampton | 15 | |||
| 10/16/2021 | Hampton | 5 | at | Charleston Southern (4-6,3-4) | 35 | |||
| 10/23/2021 | North Carolina A&T (5-6,3-4) | 9 | at | Hampton | 30 | |||
| 10/30/2021 | Hampton | 35 | at | Robert Morris (4-6,3-5) | 38 | |||
| 11/6/2021 | Gardner-Webb (4-7,2-5) | 21 | at | Hampton | 27 | OT | ||
| 11/13/2021 | Hampton | 28 | at | Campbell (3-8,2-5) | 21 | |||
| 11/20/2021 | North Alabama (3-8,3-4) | 35 | at | Hampton | 27 |
| vs Hampton | vs Other Opponents | Hampton compared to OOs | |
| Record: | 6-5 | 49-62 | |
| Points Scored: | 31.55 | 26.61 | -4.94 |
| Points Allowed: | 28.00 | 28.14 | -0.14 |
| Margin: | 3.55 | -1.53 | -5.08 |
| Total Points: | 59.55 | 54.75 | 4.80 |