| 9/4/2021 | Towson | 31 | at | Morgan State (2-9) | 0 | at MEAC | ||
| 9/11/2021 | Towson | 14 | at | New Hampshire (3-8,2-6) | 26 | |||
| 9/18/2021 | North Dakota State (14-1) | 35 | at | Towson | 7 | MVC | ||
| 9/25/2021 | Towson | 21 | vs | San Diego State (12-2) | 48 | Carson CA | vs MW | |
| 10/9/2021 | Stony Brook (5-6,4-4) | 14 | at | Towson | 21 | |||
| 10/16/2021 | Rhode Island (7-4,4-4) | 7 | at | Towson | 28 | |||
| 10/23/2021 | Towson | 14 | at | William & Mary (6-5,4-4) | 40 | |||
| 10/30/2021 | Albany NY (2-9,1-7) | 24 | at | Towson | 38 | |||
| 11/6/2021 | Towson | 17 | at | Richmond (6-5,4-4) | 28 | |||
| 11/13/2021 | Elon (6-5,5-3) | 37 | at | Towson | 14 | |||
| 11/20/2021 | Towson | 10 | at | James Madison (12-2,7-1) | 56 |
| vs Towson | vs Other Opponents | Towson compared to OOs | |
| Record: | 7-4 | 68-52 | |
| Points Scored: | 28.64 | 24.53 | -4.11 |
| Points Allowed: | 19.55 | 22.39 | -2.84 |
| Margin: | 9.09 | 2.14 | -6.95 |
| Total Points: | 48.19 | 46.92 | 1.27 |