| 9/4/2021 | UNC Pembroke (5-5) | at | Winston-Salem State | Canceled COVID | MtnE | |||
| 9/11/2021 | Winston-Salem State | 6 | at | Catawba (5-4) | 28 | at SAC | ||
| 9/18/2021 | Winston-Salem State | 13 | at | North Carolina Central (6-5) | 20 | at MEAC | ||
| 9/25/2021 | Elizabeth City State (3-7,3-5) | 19 | at | Winston-Salem State | 14 | |||
| 10/2/2021 | Winston-Salem State | 7 | at | Chowan (7-3,4-3) | 73 | |||
| 10/9/2021 | Winston-Salem State | 26 | at | Johnson C Smith (1-7,1-5) | 12 | |||
| 10/16/2021 | St Augustine's (1-7,1-6) | 0 | at | Winston-Salem State | 41 | |||
| 10/23/2021 | Livingstone (1-8,1-5) | 0 | at | Winston-Salem State | 21 | |||
| 10/30/2021 | Winston-Salem State | 14 | at | Shaw (6-4,5-2) | 38 | |||
| 11/6/2021 | Winston-Salem State | 3 | at | Fayetteville State (8-2,8-1) | 10 |
| vs Winston-Salem State | vs Other Opponents | Winston-Salem State compared to OOs | |
| Record: | 6-3 | 37-49 | |
| Points Scored: | 22.22 | 22.08 | -0.14 |
| Points Allowed: | 16.11 | 26.91 | -10.80 |
| Margin: | 6.11 | -4.83 | -10.94 |
| Total Points: | 38.33 | 48.99 | -10.66 |