| 9/4/2021 | Bethune-Cookman | 28 | at | UTEP (7-6) | 38 | at CUSA | ||
| 9/11/2021 | Bethune-Cookman | 14 | at | UCF (9-4) | 63 | at AAC | ||
| 9/16/2021 | Alabama A&M (7-3,5-3) | 30 | at | Bethune-Cookman | 27 | |||
| 9/25/2021 | Bethune-Cookman | 24 | at | Alabama State (5-6,3-5) | 38 | |||
| 10/2/2021 | Bethune-Cookman | 35 | at | South Carolina State (7-5) | 42 | at MEAC | ||
| 10/9/2021 | Mississippi Valley State (4-7,3-5) | 20 | at | Bethune-Cookman | 14 | |||
| 10/16/2021 | Prairie View (7-5,6-3) | 35 | at | Bethune-Cookman | 29 | |||
| 10/23/2021 | Bethune-Cookman | 12 | at | Jackson State (11-2,9-0) | 42 | |||
| 11/6/2021 | Alcorn State (6-5,5-3) | 31 | at | Bethune-Cookman | 35 | |||
| 11/13/2021 | Bethune-Cookman | 31 | at | Grambling (4-7,3-5) | 14 | |||
| 11/20/2021 | Bethune-Cookman | 21 | vs | Florida A&M (9-3,7-1) | 46 | Orlando FL |
| vs Bethune-Cookman | vs Other Opponents | Bethune-Cookman compared to OOs | |
| Record: | 9-2 | 67-51 | |
| Points Scored: | 36.27 | 24.97 | -11.30 |
| Points Allowed: | 24.55 | 25.32 | -0.77 |
| Margin: | 11.72 | -0.35 | -12.07 |
| Total Points: | 60.82 | 50.29 | 10.53 |