| 9/4/2021 | South Carolina State (7-5) | 41 | at | Alabama A&M | 42 | MEAC | ||
| 9/16/2021 | Alabama A&M | 30 | at | Bethune-Cookman (2-9,2-6) | 27 | |||
| 9/25/2021 | Tuskegee (3-8) | 35 | vs | Alabama A&M | 45 | Mobile AL | SIAC (D2) | |
| 10/2/2021 | Alabama A&M | 28 | at | Grambling (4-7,3-5) | 37 | |||
| 10/9/2021 | Jackson State (11-2,9-0) | 61 | at | Alabama A&M | 15 | |||
| 10/16/2021 | Florida A&M (9-3,7-1) | 35 | at | Alabama A&M | 31 | |||
| 10/30/2021 | Alabama A&M | 42 | vs | Alabama State (5-6,3-5) | 28 | Birmingham AL | ||
| 11/6/2021 | Mississippi Valley State (4-7,3-5) | 14 | at | Alabama A&M | 42 | |||
| 11/13/2021 | Alabama A&M | 52 | at | Texas Southern (3-8,2-6) | 49 | |||
| 11/20/2021 | Ark Pine Bluff (2-9,1-7) | 24 | at | Alabama A&M | 52 |
| vs Alabama A&M | vs Other Opponents | Alabama A&M compared to OOs | |
| Record: | 3-7 | 47-57 | |
| Points Scored: | 35.10 | 22.55 | -12.55 |
| Points Allowed: | 37.90 | 26.88 | 11.02 |
| Margin: | -2.80 | -4.33 | -1.53 |
| Total Points: | 73.00 | 49.43 | 23.57 |