| 9/2/2021 | Reinhardt | 25 | at | Kennesaw St | 35 | MSC (NAIA) | ||
| 9/4/2021 | Robert Morris | vs | Dayton | Canceled COVID | vs Pio | |||
| North Carolina A&T | 18 | at | Furman | 29 | @ SoCon | |||
| Gardner-Webb | 25 | at | Georgia Southern | 30 | @ SBC (1A) | |||
| Virginia Union | 28 | at | Hampton | 42 | CIAA (D2) | |||
| Campbell | 7 | at | Liberty | 48 | @ Ind (1A) | |||
| Monmouth NJ | 15 | at | Middle Tenn State | 50 | @ CUSA (1A) | |||
| Southeastern Louisiana | 49 | at | North Alabama | 28 | SLC | |||
| 9/10/2021 | North Carolina A&T | 17 | at | Duke | 45 | @ ACC (1A) | ||
| 9/11/2021 | Elon | 24 | at | Campbell | 23 | CAAF | ||
| Robert Morris | 0 | at | Central Michigan | 45 | @ MAC (1A) | |||
| Monmouth NJ | 26 | at | Fordham | 23 | @ Pat | |||
| Kennesaw St | 17 | at | Georgia Tech | 45 | @ ACC (1A) | |||
| Chattanooga | 20 | at | North Alabama | 0 | SoCon | |||
| Hampton | 7 | at | Old Dominion | 47 | @ CUSA (1A) | |||
| Charleston Southern | 38 | at | The Citadel | 21 | @ SoCon | |||
| Gardner-Webb | 10 | at | UNC-Charlotte | 38 | @ CUSA (1A) | |||
| 9/18/2021 | Presbyterian | 0 | at | Campbell | 72 | Pio | ||
| Monmouth NJ | 41 | at | Charleston Southern | 14 | ||||
| Lincoln PA | 0 | at | Gardner-Webb | 56 | CIAA (D2) | |||
| Hampton | 48 | at | Howard | 32 | @ MEAC | |||
| North Alabama | 24 | at | Jacksonville State | 27 | @ WAC | |||
| Kennesaw St | 31 | at | Wofford | 10 | @ SoCon | |||
| 9/25/2021 | Charleston Southern | 28 | at | East Carolina | 31 | @ AAC (1A) | ||
| Western Carolina | 34 | at | Gardner-Webb | 52 | SoCon | |||
| Holy Cross | 45 | at | Monmouth NJ | 15 | Pat | |||
| North Alabama | 14 | at | Nicholls State | 31 | @ SLC | |||
| North Carolina Central | 14 | at | North Carolina A&T | 37 | MEAC | |||
| Howard | 16 | at | Robert Morris | 22 | MEAC | |||
| 10/2/2021 | Norfolk State | 47 | at | Hampton | 44 | OT | MEAC | |
| Jacksonville State | 6 | at | Kennesaw St | 31 | WAC | |||
| Gardner-Webb | 17 | at | Monmouth NJ | 54 | ||||
| Campbell | 48 | at | North Alabama | 31 | ||||
| Robert Morris | 14 | at | North Carolina A&T | 41 | ||||
| 10/9/2021 | Campbell | 42 | at | Gardner-Webb | 28 | |||
| Kennesaw St | 34 | at | Hampton | 15 | ||||
| Princeton | 31 | at | Monmouth NJ | 28 | Ivy | |||
| North Alabama | 34 | at | North Carolina A&T | 38 | ||||
| Charleston Southern | 24 | at | Robert Morris | 31 | ||||
| 10/16/2021 | Monmouth NJ | 34 | at | Campbell | 17 | |||
| Hampton | 5 | at | Charleston Southern | 35 | ||||
| North Carolina A&T | 0 | at | Kennesaw St | 14 | ||||
| Robert Morris | 31 | at | North Alabama | 42 | ||||
| 10/23/2021 | Kennesaw St | 30 | at | Campbell | 7 | |||
| Robert Morris | 17 | at | Gardner-Webb | 28 | ||||
| North Carolina A&T | 9 | at | Hampton | 30 | ||||
| Charleston Southern | 22 | at | North Alabama | 45 | ||||
| 10/30/2021 | Campbell | 14 | at | Charleston Southern | 27 | |||
| Gardner-Webb | 30 | at | Kennesaw St | 34 | ||||
| Monmouth NJ | 35 | at | North Carolina A&T | 16 | ||||
| Hampton | 35 | at | Robert Morris | 38 | ||||
| 11/6/2021 | North Carolina A&T | 21 | at | Charleston Southern | 18 | |||
| Gardner-Webb | 21 | at | Hampton | 27 | OT | |||
| Campbell | 14 | at | James Madison | 51 | @ CAAF | |||
| North Alabama | 33 | at | Monmouth NJ | 45 | ||||
| Kennesaw St | 45 | at | Robert Morris | 21 | ||||
| 11/13/2021 | Hampton | 28 | at | Campbell | 21 | |||
| Charleston Southern | 32 | at | Gardner-Webb | 24 | 2OT | |||
| Robert Morris | 7 | at | Monmouth NJ | 44 | ||||
| Kennesaw St | 28 | at | North Alabama | 24 | ||||
| North Carolina A&T | 27 | at | South Carolina State | 17 | @ MEAC | |||
| 11/20/2021 | Charleston Southern | 7 | at | Georgia | 56 | @ SEC (1A) | ||
| North Alabama | 35 | at | Hampton | 27 | ||||
| Monmouth NJ | 17 | at | Kennesaw St | 49 | ||||
| Gardner-Webb | 35 | at | North Carolina A&T | 27 | ||||
| Campbell | 17 | at | Robert Morris | 20 | OT | |||
| 11/27/2021 | Davidson | 21 | at | Kennesaw St | 48 | Pio | ||
| 12/4/2021 | Kennesaw St | 31 | at | East Tennessee St | 32 | @ SoCon |