| 9/4/2021 | St Andrews (1-9) | 43 | at | Presbyterian | 84 | MSC (NAIA) | ||
| 9/11/2021 | Fort Lauderdale (0-7) | 3 | at | Presbyterian | 68 | None (Unk?) | ||
| 9/18/2021 | Presbyterian | 0 | at | Campbell (3-8) | 72 | at BigS | ||
| 9/25/2021 | Presbyterian | 43 | at | Dayton (6-4,5-3) | 63 | |||
| 10/9/2021 | Morehead State (7-4,6-2) | 38 | at | Presbyterian | 30 | |||
| 10/16/2021 | Presbyterian | 35 | at | Davidson (8-3,7-1) | 70 | |||
| 10/23/2021 | San Diego (7-4,7-1) | 69 | at | Presbyterian | 28 | |||
| 10/30/2021 | Stetson (3-7,1-6) | 56 | at | Presbyterian | 14 | |||
| 11/6/2021 | Presbyterian | 55 | at | Valparaiso (4-7,4-4) | 65 | |||
| 11/13/2021 | Marist (5-5,5-3) | 57 | at | Presbyterian | 32 | |||
| 11/20/2021 | Presbyterian | 15 | at | St Thomas (7-3,6-2) | 54 |
| vs Presbyterian | vs Other Opponents | Presbyterian compared to OOs | |
| Record: | 9-2 | 42-59 | |
| Points Scored: | 53.64 | 23.99 | -29.65 |
| Points Allowed: | 36.73 | 31.22 | 5.51 |
| Margin: | 16.91 | -7.23 | -24.14 |
| Total Points: | 90.37 | 55.21 | 35.16 |