| 9/4/2021 | Wofford (1-10) | 24 | at | Elon | 22 | SoCon | ||
| 9/11/2021 | Elon | 24 | at | Campbell (3-8) | 23 | at BigS | ||
| 9/18/2021 | Elon | 10 | at | Appalachian State (10-4) | 44 | at SBC | ||
| 9/25/2021 | William & Mary (6-5,4-4) | 34 | at | Elon | 31 | |||
| 10/2/2021 | Elon | 20 | at | Richmond (6-5,4-4) | 7 | |||
| 10/9/2021 | Elon | 33 | at | Maine (6-5,4-4) | 23 | |||
| 10/23/2021 | New Hampshire (3-8,2-6) | 10 | at | Elon | 24 | |||
| 10/30/2021 | Elon | 21 | at | James Madison (12-2,7-1) | 45 | |||
| 11/6/2021 | Villanova (10-3,7-1) | 35 | at | Elon | 0 | |||
| 11/13/2021 | Elon | 37 | at | Towson (4-7,3-5) | 14 | |||
| 11/20/2021 | Rhode Island (7-4,4-4) | 28 | at | Elon | 43 |
| vs Elon | vs Other Opponents | Elon compared to OOs | |
| Record: | 5-6 | 63-55 | |
| Points Scored: | 26.09 | 26.17 | 0.08 |
| Points Allowed: | 24.09 | 24.23 | -0.14 |
| Margin: | 2.00 | 1.94 | -0.06 |
| Total Points: | 50.18 | 50.40 | -0.22 |