| 9/1/2021 | UAB (9-4) | 31 | vs | Jacksonville State | 0 | Montgomery AL | CUSA (1A) | |
| 9/11/2021 | Jacksonville State | 20 | at | Florida State (5-7) | 17 | at ACC | ||
| 9/18/2021 | North Alabama (3-8) | 24 | at | Jacksonville State | 27 | BigS | ||
| 9/25/2021 | Tennessee-Martin (10-3) | 34 | at | Jacksonville State | 31 | OVC | ||
| 10/2/2021 | Jacksonville State | 6 | at | Kennesaw St (11-2) | 31 | at BigS | ||
| 10/9/2021 | Stephen F. Austin (8-4,6-2) | 24 | at | Jacksonville State | 28 | |||
| 10/23/2021 | Jacksonville State | 7 | at | Sam Houston (11-1,8-0) | 42 | |||
| 10/30/2021 | Central Arkansas (5-6,3-4) | 38 | at | Jacksonville State | 14 | |||
| 11/6/2021 | Abilene Christian (5-6,3-5) | 25 | at | Jacksonville State | 40 | |||
| 11/13/2021 | Jacksonville State | 38 | at | Lamar (2-9,0-8) | 7 | |||
| 11/20/2021 | Jacksonville State | 31 | at | Eastern Kentucky (7-4,5-2) | 39 | 2OT |
| vs Jacksonville State | vs Other Opponents | Jacksonville State compared to OOs | |
| Record: | 6-5 | 70-49 | |
| Points Scored: | 28.36 | 30.23 | 1.87 |
| Points Allowed: | 22.00 | 25.91 | -3.91 |
| Margin: | 6.36 | 4.32 | -2.04 |
| Total Points: | 50.36 | 56.14 | -5.78 |