| 9/4/2021 | Nicholls State | 17 | at | Memphis (6-6) | 42 | at AAC | ||
| 9/11/2021 | Nicholls State | 24 | at | UL Lafayette (13-1) | 27 | at SBC | ||
| 9/25/2021 | North Alabama (3-8) | 14 | at | Nicholls State | 31 | BigS | ||
| 10/2/2021 | Houston Baptist (0-11,0-8) | 17 | at | Nicholls State | 48 | |||
| 10/9/2021 | Southeastern Louisiana (9-4,6-2) | 58 | at | Nicholls State | 48 | |||
| 10/16/2021 | Nicholls State | 21 | at | Incarnate Word (10-3,7-1) | 38 | |||
| 10/23/2021 | Nicholls State | 44 | at | Houston Baptist (0-11,0-8) | 14 | |||
| 10/30/2021 | Northwestern State (3-8,3-5) | 21 | at | Nicholls State | 42 | |||
| 11/6/2021 | Nicholls State | 24 | at | McNeese State (4-7,3-5) | 14 | |||
| 11/13/2021 | Incarnate Word (10-3,7-1) | 27 | at | Nicholls State | 23 | |||
| 11/18/2021 | Nicholls State | 45 | at | Southeastern Louisiana (9-4,6-2) | 42 |
| vs Nicholls State | vs Other Opponents | Nicholls State compared to OOs | |
| Record: | 5-6 | 59-57 | |
| Points Scored: | 28.55 | 33.24 | 4.69 |
| Points Allowed: | 33.36 | 32.17 | 1.19 |
| Margin: | -4.81 | 1.07 | 5.88 |
| Total Points: | 61.91 | 65.41 | -3.50 |