| 9/4/2021 | North Carolina A&T (5-6) | 18 | at | Furman | 29 | BigS | ||
| 9/11/2021 | Furman | 26 | at | Tennessee Tech (3-8) | 0 | at OVC | ||
| 9/18/2021 | Furman | 7 | at | North Carolina State (9-3) | 45 | at ACC | ||
| 9/25/2021 | Mercer (7-3,6-2) | 24 | at | Furman | 3 | |||
| 10/9/2021 | Furman | 42 | at | Wofford (1-10,0-8) | 20 | |||
| 10/16/2021 | The Citadel (4-7,3-5) | 14 | at | Furman | 24 | |||
| 10/23/2021 | East Tennessee St (11-2,7-1) | 17 | at | Furman | 13 | |||
| 10/30/2021 | Furman | 3 | at | Chattanooga (6-5,5-3) | 13 | |||
| 11/6/2021 | Furman | 42 | at | Western Carolina (4-7,4-4) | 43 | |||
| 11/13/2021 | VMI (6-5,4-4) | 31 | at | Furman | 37 | |||
| 11/20/2021 | Furman | 41 | at | Samford (4-7,3-5) | 34 |
| vs Furman | vs Other Opponents | Furman compared to OOs | |
| Record: | 5-6 | 55-57 | |
| Points Scored: | 23.55 | 28.92 | 5.37 |
| Points Allowed: | 24.27 | 29.69 | -5.42 |
| Margin: | -0.72 | -0.77 | -0.05 |
| Total Points: | 47.82 | 58.61 | -10.79 |