| 9/4/2021 | Wofford | 24 | at | Elon (6-5) | 22 | at CAAF | ||
| 9/18/2021 | Kennesaw St (11-2) | 31 | at | Wofford | 10 | BigS | ||
| 9/25/2021 | Wofford | 23 | at | VMI (6-5,4-4) | 31 | |||
| 10/2/2021 | Wofford | 21 | at | East Tennessee St (11-2,7-1) | 27 | |||
| 10/9/2021 | Furman (6-5,4-4) | 42 | at | Wofford | 20 | |||
| 10/16/2021 | Samford (4-7,3-5) | 27 | at | Wofford | 24 | |||
| 10/23/2021 | Wofford | 14 | at | Mercer (7-3,6-2) | 45 | |||
| 10/30/2021 | Western Carolina (4-7,4-4) | 41 | at | Wofford | 21 | |||
| 11/6/2021 | Chattanooga (6-5,5-3) | 35 | at | Wofford | 10 | |||
| 11/13/2021 | Wofford | 44 | at | The Citadel (4-7,3-5) | 45 | OT | ||
| 11/20/2021 | Wofford | 14 | at | North Carolina (6-7) | 34 | at ACC |
| vs Wofford | vs Other Opponents | Wofford compared to OOs | |
| Record: | 10-1 | 61-54 | |
| Points Scored: | 34.55 | 30.09 | -4.46 |
| Points Allowed: | 20.45 | 28.97 | -8.52 |
| Margin: | 14.10 | 1.12 | -12.98 |
| Total Points: | 55.00 | 59.06 | -4.06 |