| 8/28/2021 | Alcorn State (6-5) | 14 | vs | North Carolina Central | 23 | Atlanta GA | SWAC | |
| 9/11/2021 | North Carolina Central | 10 | at | Marshall (7-6) | 44 | at CUSA | ||
| 9/18/2021 | Winston-Salem State (3-6) | 13 | at | North Carolina Central | 20 | CIAA (D2) | ||
| 9/25/2021 | North Carolina Central | 14 | at | North Carolina A&T (5-6) | 37 | at BigS | ||
| 10/2/2021 | North Carolina Central | 16 | at | Mississippi Valley State (4-7) | 17 | at SWAC | ||
| 10/9/2021 | Tennessee Tech (3-8) | 27 | at | North Carolina Central | 16 | OVC | ||
| 10/23/2021 | North Carolina Central | 28 | at | Morgan State (2-9,1-4) | 17 | |||
| 10/30/2021 | South Carolina State (7-5,5-0) | 27 | at | North Carolina Central | 24 | |||
| 11/6/2021 | Norfolk State (6-5,2-3) | 36 | at | North Carolina Central | 38 | 2OT | ||
| 11/13/2021 | North Carolina Central | 45 | at | Howard (3-8,1-4) | 27 | |||
| 11/20/2021 | Delaware State (5-6,2-3) | 28 | at | North Carolina Central | 34 | OT |
| vs North Carolina Central | vs Other Opponents | North Carolina Central compared to OOs | |
| Record: | 5-6 | 46-65 | |
| Points Scored: | 26.09 | 23.23 | -2.86 |
| Points Allowed: | 24.36 | 27.94 | -3.58 |
| Margin: | 1.73 | -4.71 | -6.44 |
| Total Points: | 50.45 | 51.17 | -0.72 |