| 9/4/2021 | Robert Morris (4-6) | vs | Dayton | Canceled COVID | BigS | |||
| 9/11/2021 | Eastern Illinois (1-10) | 10 | at | Dayton | 17 | OVC | ||
| 9/18/2021 | Dayton | 3 | at | Southern Illinois (8-5) | 55 | at MVC | ||
| 9/25/2021 | Presbyterian (2-9,0-8) | 43 | at | Dayton | 63 | |||
| 10/2/2021 | Dayton | 38 | at | Morehead State (7-4,6-2) | 45 | OT | ||
| 10/9/2021 | Dayton | 28 | at | Drake (2-8,1-6) | 10 | |||
| 10/16/2021 | Marist (5-5,5-3) | 20 | at | Dayton | 17 | |||
| 10/23/2021 | Dayton | 28 | at | Valparaiso (4-7,4-4) | 45 | |||
| 10/30/2021 | Butler (3-8,1-7) | 31 | at | Dayton | 38 | |||
| 11/6/2021 | Dayton | 41 | at | Stetson (3-7,1-6) | 13 | |||
| 11/13/2021 | Davidson (8-3,7-1) | 29 | at | Dayton | 38 |
| vs Dayton | vs Other Opponents | Dayton compared to OOs | |
| Record: | 4-6 | 43-66 | |
| Points Scored: | 30.10 | 25.71 | -4.39 |
| Points Allowed: | 31.10 | 31.61 | -0.51 |
| Margin: | -1.00 | -5.90 | -4.90 |
| Total Points: | 61.20 | 57.32 | 3.88 |