| 9/3/2021 | Duke (3-9) | 28 | at | UNC-Charlotte | 31 | ACC | ||
| 9/11/2021 | Gardner-Webb (4-7) | 10 | at | UNC-Charlotte | 38 | BigS (1AA) | ||
| 9/18/2021 | UNC-Charlotte | 9 | at | Georgia State (8-5) | 20 | at SBC | ||
| 9/24/2021 | Middle Tenn State (7-6,4-4) | 39 | at | UNC-Charlotte | 42 | |||
| 10/2/2021 | UNC-Charlotte | 14 | at | Illinois (5-7) | 24 | at B10 | ||
| 10/8/2021 | UNC-Charlotte | 45 | at | Florida Intl (1-11,0-8) | 33 | |||
| 10/21/2021 | Florida Atlantic (5-7,3-5) | 38 | at | UNC-Charlotte | 9 | |||
| 10/30/2021 | UNC-Charlotte | 13 | at | Western Kentucky (9-5,7-2) | 45 | |||
| 11/6/2021 | Rice (4-8,3-5) | 24 | at | UNC-Charlotte | 31 | OT | ||
| 11/13/2021 | UNC-Charlotte | 32 | at | Louisiana Tech (3-9,2-6) | 42 | |||
| 11/20/2021 | Marshall (7-6,5-3) | 49 | at | UNC-Charlotte | 28 | |||
| 11/27/2021 | UNC-Charlotte | 34 | at | Old Dominion (6-7,5-3) | 56 |
| vs UNC-Charlotte | vs Other Opponents | UNC-Charlotte compared to OOs | |
| Record: | 7-5 | 55-82 | |
| Points Scored: | 34.00 | 27.28 | -6.72 |
| Points Allowed: | 27.17 | 30.24 | -3.07 |
| Margin: | 6.83 | -2.96 | -9.79 |
| Total Points: | 61.17 | 57.52 | 3.65 |