| 8/31/2017 | Tulsa | 24 | at | Oklahoma State | 59 | AAC | ||
| 9/2/2017 | Liberty | 48 | at | Baylor | 45 | BigS (1AA) | ||
| Northern Iowa | 24 | at | Iowa State | 42 | MVC (1AA) | |||
| SE Missouri State | 16 | at | Kansas | 38 | OVC (1AA) | |||
| Central Arkansas | 19 | at | Kansas State | 55 | SLC (1AA) | |||
| UTEP | 7 | at | Oklahoma | 56 | CUSA | |||
| Jackson State | 0 | at | TCU | 63 | SWAC (1AA) | |||
| Maryland | 51 | at | Texas | 41 | B10 | |||
| Eastern Washington | 10 | at | Texas Tech | 56 | BSky (1AA) | |||
| 9/3/2017 | West Virginia | 24 | vs | Virginia Tech | 31 | Landover MD | vs ACC | |
| 9/8/2017 | Oklahoma State | 44 | at | South Alabama | 7 | @ SBC | ||
| 9/9/2017 | TCU | 28 | at | Arkansas | 7 | @ SEC | ||
| Texas-San Antonio | 17 | at | Baylor | 10 | CUSA | |||
| Iowa | 44 | at | Iowa State | 41 | OT | B10 | ||
| Central Michigan | 45 | at | Kansas | 27 | MAC | |||
| UNC-Charlotte | 7 | at | Kansas State | 55 | CUSA | |||
| Oklahoma | 31 | at | Ohio State | 16 | @ B10 | |||
| San Jose State | 0 | at | Texas | 56 | MW | |||
| East Carolina | 20 | at | West Virginia | 56 | AAC | |||
| 9/16/2017 | Iowa State | 41 | at | Akron | 14 | @ MAC | ||
| Baylor | 20 | at | Duke | 34 | @ ACC | |||
| Kansas | 30 | at | Ohio | 42 | @ MAC | |||
| Tulane | 14 | at | Oklahoma | 56 | AAC | |||
| Oklahoma State | 59 | at | Pittsburgh | 21 | @ ACC | |||
| Texas | 24 | at | Southern California | 27 | 2OT | @ P12 | ||
| SMU | 36 | at | TCU | 56 | AAC | |||
| Arizona State | 45 | at | Texas Tech | 52 | P12 | |||
| Kansas State | 7 | at | Vanderbilt | 14 | @ SEC | |||
| Delaware State | 16 | at | West Virginia | 59 | MEAC (1AA) | |||
| 9/23/2017 | Oklahoma | 49 | at | Baylor | 41 | |||
| Texas Tech | 27 | at | Houston | 24 | @ AAC | |||
| West Virginia | 56 | at | Kansas | 34 | ||||
| TCU | 44 | at | Oklahoma State | 31 | ||||
| 9/28/2017 | Texas | 17 | at | Iowa State | 7 | |||
| 9/30/2017 | Baylor | 20 | at | Kansas State | 33 | |||
| Oklahoma State | 41 | at | Texas Tech | 34 | ||||
| 10/7/2017 | Texas Tech | 65 | at | Kansas | 19 | |||
| Iowa State | 38 | at | Oklahoma | 31 | ||||
| West Virginia | 24 | at | TCU | 31 | ||||
| Kansas State | 34 | at | Texas | 40 | 2OT | |||
| 10/14/2017 | Kansas | 0 | at | Iowa State | 45 | |||
| TCU | 26 | at | Kansas State | 6 | ||||
| Baylor | 16 | at | Oklahoma State | 59 | ||||
| Oklahoma | 29 | vs | Texas | 24 | Dallas TX | |||
| Texas Tech | 35 | at | West Virginia | 46 | ||||
| 10/21/2017 | West Virginia | 38 | at | Baylor | 36 | |||
| Oklahoma | 42 | at | Kansas State | 35 | ||||
| Kansas | 0 | at | TCU | 43 | ||||
| Oklahoma State | 13 | at | Texas | 10 | OT | |||
| Iowa State | 31 | at | Texas Tech | 13 | ||||
| 10/28/2017 | Texas | 38 | at | Baylor | 7 | |||
| TCU | 7 | at | Iowa State | 14 | ||||
| Kansas State | 30 | at | Kansas | 20 | ||||
| Texas Tech | 27 | at | Oklahoma | 49 | ||||
| Oklahoma State | 50 | at | West Virginia | 39 | ||||
| 11/4/2017 | Baylor | 38 | at | Kansas | 9 | |||
| Oklahoma | 62 | at | Oklahoma State | 52 | ||||
| Texas | 7 | at | TCU | 24 | ||||
| Kansas State | 42 | at | Texas Tech | 35 | OT | |||
| Iowa State | 16 | at | West Virginia | 20 | ||||
| 11/11/2017 | Texas Tech | 38 | vs | Baylor | 24 | Arlington TX | ||
| Oklahoma State | 49 | at | Iowa State | 42 | ||||
| West Virginia | 28 | at | Kansas State | 23 | ||||
| TCU | 20 | at | Oklahoma | 38 | ||||
| Kansas | 27 | at | Texas | 42 | ||||
| 11/18/2017 | Iowa State | 23 | at | Baylor | 13 | |||
| Oklahoma | 41 | at | Kansas | 3 | ||||
| Kansas State | 45 | at | Oklahoma State | 40 | ||||
| TCU | 27 | at | Texas Tech | 3 | ||||
| Texas | 28 | at | West Virginia | 14 | ||||
| 11/24/2017 | Baylor | 22 | at | TCU | 45 | |||
| Texas Tech | 27 | at | Texas | 23 | ||||
| 11/25/2017 | Iowa State | 19 | at | Kansas State | 20 | |||
| West Virginia | 31 | at | Oklahoma | 59 | ||||
| Kansas | 17 | at | Oklahoma State | 58 | ||||
| 12/2/2017 | TCU | 17 | vs | Oklahoma | 41 | Big12 Championship (Arlington TX) | ||
| 12/23/2017 | Texas Tech | 34 | vs | South Florida | 38 | Birmingham Bowl (Birmingham AL) | vs AAC | |
| 12/26/2017 | Kansas State | 35 | vs | UCLA | 17 | Cactus Bowl (Phoenix AZ) | vs P12 | |
| Utah | 30 | vs | West Virginia | 14 | Heart of Dallas Bowl (Dallas TX) | vs P12 | ||
| 12/27/2017 | Texas | 33 | vs | Missouri | 16 | Texas Bowl (Houston TX) | vs SEC | |
| 12/28/2017 | Virginia Tech | 21 | vs | Oklahoma State | 30 | Camping World Bowl (Orlando FL) | vs ACC | |
| Stanford | 37 | vs | TCU | 39 | Alamo Bowl (San Antonio TX) | vs P12 | ||
| 12/30/2017 | Iowa State | 21 | vs | Memphis | 20 | Liberty Bowl (Memphis TN) | vs AAC | |
| 1/1/2018 | Georgia | 54 | vs | Oklahoma | 48 | 2OT | Rose Bowl (Pasadena CA) | vs SEC |