| 9/2/2017 | Western Michigan (6-6) | 31 | at | Southern California | 49 | | | MAC |
| 9/9/2017 | Stanford (9-5,7-3) | 24 | at | Southern California | 42 | | | |
| 9/16/2017 | Texas (7-6) | 24 | at | Southern California | 27 | 2OT | | B12 |
| 9/23/2017 | Southern California | 30 | at | California (5-7,2-7) | 20 | | | |
| 9/29/2017 | Southern California | 27 | at | Washington State (9-4,6-3) | 30 | | | |
| 10/7/2017 | Oregon State (1-11,0-9) | 10 | at | Southern California | 38 | | | |
| 10/14/2017 | Utah (7-6,3-6) | 27 | at | Southern California | 28 | | | |
| 10/21/2017 | Southern California | 14 | at | Notre Dame (10-3) | 49 | | | at ND |
| 10/28/2017 | Southern California | 48 | at | Arizona State (7-6,6-3) | 17 | | | |
| 11/4/2017 | Arizona (7-6,5-4) | 35 | at | Southern California | 49 | | | |
| 11/11/2017 | Southern California | 38 | at | Colorado (5-7,2-7) | 24 | | | |
| 11/18/2017 | UCLA (6-7,4-5) | 23 | at | Southern California | 28 | | | |
| 12/1/2017 | Stanford (9-5,7-3) | 28 | vs | Southern California | 31 | | Pac 12 Championship (Santa Clara CA) | |
| 12/29/2017 | Southern California | 7 | vs | Ohio State (12-2) | 24 | | Cotton Bowl (Arlington TX) | vs B10 |