| 9/2/2017 | Vanderbilt | 28 | at | Middle Tenn State (7-6) | 6 | at CUSA | ||
| 9/9/2017 | Alabama A&M (4-7) | 0 | at | Vanderbilt | 42 | SWAC (1AA) | ||
| 9/16/2017 | Kansas State (8-5) | 7 | at | Vanderbilt | 14 | B12 | ||
| 9/23/2017 | Alabama (13-1,8-1) | 59 | at | Vanderbilt | 0 | |||
| 9/30/2017 | Vanderbilt | 24 | at | Florida (4-7,3-5) | 38 | |||
| 10/7/2017 | Georgia (13-2,8-2) | 45 | at | Vanderbilt | 14 | |||
| 10/14/2017 | Vanderbilt | 35 | at | Mississippi (6-6,3-5) | 57 | |||
| 10/28/2017 | Vanderbilt | 27 | at | South Carolina (9-4,5-3) | 34 | |||
| 11/4/2017 | Western Kentucky (6-7) | 17 | at | Vanderbilt | 31 | CUSA | ||
| 11/11/2017 | Kentucky (7-6,4-4) | 44 | at | Vanderbilt | 21 | |||
| 11/18/2017 | Missouri (7-6,4-4) | 45 | at | Vanderbilt | 17 | |||
| 11/25/2017 | Vanderbilt | 42 | at | Tennessee (4-8,0-8) | 24 |
| vs Vanderbilt | vs Other Opponents | Vanderbilt compared to OOs | |
| Record: | 7-5 | 81-60 | |
| Points Scored: | 31.33 | 28.09 | -3.24 |
| Points Allowed: | 24.58 | 24.97 | -0.39 |
| Margin: | 6.75 | 3.12 | -3.63 |
| Total Points: | 55.91 | 53.06 | 2.85 |