| 8/26/2017 | South Florida | 42 | at | San Jose State (2-11) | 22 | at MW | ||
| 9/2/2017 | Stony Brook (10-3) | 17 | at | South Florida | 31 | CAAF (1AA) | ||
| 9/9/2017 | South Florida | at | Connecticut (3-9,2-6) | Cancelled WX | ||||
| 9/15/2017 | Illinois (2-10) | 23 | at | South Florida | 47 | B10 | ||
| 9/21/2017 | Temple (7-6,4-4) | 7 | at | South Florida | 43 | |||
| 9/30/2017 | South Florida | 61 | at | East Carolina (3-9,2-6) | 31 | |||
| 10/14/2017 | Massachusetts (4-8) | at | South Florida | Cancelled | Ind | |||
| Cincinnati (4-8,2-6) | 3 | at | South Florida | 33 | ||||
| 10/21/2017 | South Florida | 34 | at | Tulane (5-7,3-5) | 28 | |||
| 10/28/2017 | Houston (7-5,5-3) | 28 | at | South Florida | 24 | |||
| 11/4/2017 | South Florida | 37 | at | Connecticut (3-9,2-6) | 20 | |||
| 11/16/2017 | Tulsa (2-10,1-7) | 20 | at | South Florida | 27 | |||
| 11/24/2017 | South Florida | 42 | at | UCF (13-0,9-0) | 49 | |||
| 12/23/2017 | Texas Tech (6-7) | 34 | vs | South Florida | 38 | Birmingham Bowl (Birmingham AL) | B12 |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 2-10 | 69-91 | |
| Points Scored: | 23.50 | 27.45 | 3.95 |
| Points Allowed: | 38.25 | 31.95 | 6.30 |
| Margin: | -14.75 | -4.50 | 10.25 |
| Total Points: | 61.75 | 59.40 | 2.35 |