| 9/2/2017 | Youngstown State (6-5) | 21 | at | Pittsburgh | 28 | OT | MVC (1AA) | |
| 9/9/2017 | Pittsburgh | 14 | at | Penn State (11-2) | 33 | at B10 | ||
| 9/16/2017 | Oklahoma State (10-3) | 59 | at | Pittsburgh | 21 | B12 | ||
| 9/23/2017 | Pittsburgh | 17 | at | Georgia Tech (5-6,4-4) | 35 | |||
| 9/30/2017 | Rice (1-11) | 10 | at | Pittsburgh | 42 | CUSA | ||
| 10/7/2017 | Pittsburgh | 24 | at | Syracuse (4-8,2-6) | 27 | |||
| 10/14/2017 | North Carolina State (9-4,6-2) | 35 | at | Pittsburgh | 17 | |||
| 10/21/2017 | Pittsburgh | 24 | at | Duke (7-6,3-5) | 17 | |||
| 10/28/2017 | Virginia (6-7,3-5) | 14 | at | Pittsburgh | 31 | |||
| 11/9/2017 | North Carolina (3-9,1-7) | 34 | at | Pittsburgh | 31 | |||
| 11/18/2017 | Pittsburgh | 14 | at | Virginia Tech (9-4,5-3) | 20 | |||
| 11/24/2017 | Miami-Florida (10-3,7-2) | 14 | at | Pittsburgh | 24 |
| vs Pittsburgh | vs Other Opponents | Pittsburgh compared to OOs | |
| Record: | 7-5 | 74-63 | |
| Points Scored: | 26.58 | 29.73 | 3.15 |
| Points Allowed: | 23.92 | 25.01 | -1.09 |
| Margin: | 2.66 | 4.72 | 2.06 |
| Total Points: | 50.50 | 54.74 | -4.24 |