| 9/2/2017 | Missouri State (3-8) | 43 | at | Missouri | 72 | MVC (1AA) | ||
| 9/9/2017 | South Carolina (9-4,5-3) | 31 | at | Missouri | 13 | |||
| 9/16/2017 | Purdue (7-6) | 35 | at | Missouri | 3 | B10 | ||
| 9/23/2017 | Auburn (10-4,7-2) | 51 | at | Missouri | 14 | |||
| 10/7/2017 | Missouri | 34 | at | Kentucky (7-6,4-4) | 40 | |||
| 10/14/2017 | Missouri | 28 | at | Georgia (13-2,8-2) | 53 | |||
| 10/21/2017 | Idaho (4-8) | 21 | at | Missouri | 68 | SBC | ||
| 10/28/2017 | Missouri | 52 | at | Connecticut (3-9) | 12 | at AAC | ||
| 11/4/2017 | Florida (4-7,3-5) | 16 | at | Missouri | 45 | |||
| 11/11/2017 | Tennessee (4-8,0-8) | 17 | at | Missouri | 50 | |||
| 11/18/2017 | Missouri | 45 | at | Vanderbilt (5-7,1-7) | 17 | |||
| 11/24/2017 | Missouri | 48 | at | Arkansas (4-8,1-7) | 45 | |||
| 12/27/2017 | Texas (7-6) | 33 | vs | Missouri | 16 | Texas Bowl (Houston TX) | B12 |
| vs Missouri | vs Other Opponents | Missouri compared to OOs | |
| Record: | 6-7 | 74-76 | |
| Points Scored: | 31.85 | 25.80 | -6.05 |
| Points Allowed: | 37.54 | 25.60 | 11.94 |
| Margin: | -5.69 | 0.20 | 5.89 |
| Total Points: | 69.39 | 51.40 | 17.99 |