| 9/2/2017 | North Carolina Central (7-4) | 7 | at | Duke | 60 | MEAC (1AA) | ||
| 9/9/2017 | Northwestern (10-3) | 17 | at | Duke | 41 | B10 | ||
| 9/16/2017 | Baylor (1-11) | 20 | at | Duke | 34 | B12 | ||
| 9/23/2017 | Duke | 27 | at | North Carolina (3-9,1-7) | 17 | |||
| 9/29/2017 | Miami-Florida (10-3,7-2) | 31 | at | Duke | 6 | |||
| 10/7/2017 | Duke | 21 | at | Virginia (6-7,3-5) | 28 | |||
| 10/14/2017 | Florida State (7-6,3-5) | 17 | at | Duke | 10 | |||
| 10/21/2017 | Pittsburgh (5-7,3-5) | 24 | at | Duke | 17 | |||
| 10/28/2017 | Duke | 3 | at | Virginia Tech (9-4,5-3) | 24 | |||
| 11/11/2017 | Duke | 16 | at | Army (10-3) | 21 | at Ind | ||
| 11/18/2017 | Georgia Tech (5-6,4-4) | 20 | at | Duke | 43 | |||
| 11/25/2017 | Duke | 31 | at | Wake Forest (8-5,4-4) | 23 | |||
| 12/26/2017 | Duke | 36 | vs | Northern Illinois (8-5) | 14 | Quick Lane Bowl (Detroit MI) | vs MAC |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 6-7 | 83-66 | |
| Points Scored: | 20.23 | 28.09 | 7.86 |
| Points Allowed: | 26.54 | 24.12 | 2.42 |
| Margin: | -6.31 | 3.97 | 10.28 |
| Total Points: | 46.77 | 52.21 | -5.44 |