| 8/31/2017 | Ohio State | 49 | at | Indiana (5-7,2-7) | 21 | | | |
| 9/9/2017 | Oklahoma (12-2) | 31 | at | Ohio State | 16 | | | B12 |
| 9/16/2017 | Army (10-3) | 7 | at | Ohio State | 38 | | | Ind |
| 9/23/2017 | UNLV (5-7) | 21 | at | Ohio State | 54 | | | MW |
| 9/30/2017 | Ohio State | 56 | at | Rutgers (4-8,3-6) | 0 | | | |
| 10/7/2017 | Maryland (4-8,2-7) | 14 | at | Ohio State | 62 | | | |
| 10/14/2017 | Ohio State | 56 | at | Nebraska (4-8,3-6) | 14 | | | |
| 10/28/2017 | Penn State (11-2,7-2) | 38 | at | Ohio State | 39 | | | |
| 11/4/2017 | Ohio State | 24 | at | Iowa (8-5,4-5) | 55 | | | |
| 11/11/2017 | Michigan State (10-3,7-2) | 3 | at | Ohio State | 48 | | | |
| 11/18/2017 | Illinois (2-10,0-9) | 14 | at | Ohio State | 52 | | | |
| 11/25/2017 | Ohio State | 31 | at | Michigan (8-5,5-4) | 20 | | | |
| 12/2/2017 | Ohio State | 27 | vs | Wisconsin (13-1,9-1) | 21 | | Big10 Championship (Indianapolis IN) | |
| 12/29/2017 | Southern California (11-3) | 7 | vs | Ohio State | 24 | | Cotton Bowl (Arlington TX) | P12 |