| 9/2/2017 | Houston | at | Texas-San Antonio (6-5) | Postponed | at CUSA | |||
| 9/9/2017 | Houston | 19 | at | Arizona (7-6) | 16 | at P12 | ||
| 9/16/2017 | Rice (1-11) | 3 | at | Houston | 38 | CUSA | ||
| 9/23/2017 | Texas Tech (6-7) | 27 | at | Houston | 24 | B12 | ||
| 9/30/2017 | Houston | 20 | at | Temple (7-6,4-4) | 13 | |||
| 10/7/2017 | SMU (7-6,4-4) | 22 | at | Houston | 35 | |||
| 10/14/2017 | Houston | 17 | at | Tulsa (2-10,1-7) | 45 | |||
| 10/19/2017 | Memphis (10-3,7-2) | 42 | at | Houston | 38 | |||
| 10/28/2017 | Houston | 28 | at | South Florida (10-2,6-2) | 24 | |||
| 11/4/2017 | East Carolina (3-9,2-6) | 27 | at | Houston | 52 | |||
| 11/18/2017 | Houston | 17 | at | Tulane (5-7,3-5) | 20 | |||
| 11/24/2017 | Navy (7-6,4-4) | 14 | at | Houston | 24 | |||
| 12/24/2017 | Fresno State (10-4) | 33 | vs | Houston | 27 | Hawaii Bowl (Honolulu HA) | MW |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 5-7 | 76-75 | |
| Points Scored: | 23.83 | 31.64 | 7.81 |
| Points Allowed: | 28.25 | 30.41 | -2.16 |
| Margin: | -4.42 | 1.23 | 5.65 |
| Total Points: | 52.08 | 62.05 | -9.97 |