| 9/2/2017 | Akron | 0 | at | Penn State (11-2) | 52 | | | at B10 |
| 9/9/2017 | Ark Pine Bluff (2-9) | 3 | at | Akron | 52 | | | SWAC (1AA) |
| 9/16/2017 | Iowa State (8-5) | 41 | at | Akron | 14 | | | B12 |
| 9/23/2017 | Akron | 17 | at | Troy (11-2) | 22 | | | at SBC |
| 9/30/2017 | Akron | 34 | at | Bowling Green (2-10,2-6) | 23 | | | |
| 10/7/2017 | Ball State (2-10,0-8) | 3 | at | Akron | 31 | | | |
| 10/14/2017 | Akron | | at | Western Michigan (6-6,4-4) | | | Postponed | |
| 10/15/2017 | Akron | 14 | at | Western Michigan (6-6,4-4) | 13 | | | |
| 10/21/2017 | Akron | 21 | at | Toledo (11-3,8-1) | 48 | | | |
| 10/28/2017 | Buffalo (6-6,4-4) | 20 | at | Akron | 21 | | | |
| 11/7/2017 | Akron | 14 | at | Miami-Ohio (5-7,4-4) | 24 | | | |
| 11/14/2017 | Ohio (9-4,5-3) | 34 | at | Akron | 37 | | | |
| 11/21/2017 | Kent State (2-10,1-7) | 14 | at | Akron | 24 | | | |
| 12/2/2017 | Akron | 28 | vs | Toledo (11-3,8-1) | 45 | | MAC Championship (Detroit MI) | |
| 12/19/2017 | Akron | 3 | vs | Florida Atlantic (11-3) | 50 | | Boca Raton Bowl (Boca Raton FL) | vs CUSA |