| 9/2/2017 | SE Missouri State | 16 | at | Kansas (1-11) | 38 | at B12 | ||
| 9/9/2017 | SE Missouri State | 23 | at | Dayton (5-6) | 25 | at Pio | ||
| 9/16/2017 | Southern Illinois (4-7) | 35 | at | SE Missouri State | 17 | MVC | ||
| 9/23/2017 | SE Missouri State | 16 | at | Eastern Illinois (6-5,5-3) | 19 | |||
| 9/30/2017 | Eastern Kentucky (4-7,3-5) | 10 | at | SE Missouri State | 29 | |||
| 10/14/2017 | Tennessee Tech (1-10,1-7) | 3 | at | SE Missouri State | 31 | |||
| 10/21/2017 | SE Missouri State | 31 | at | Austin Peay (8-4,7-1) | 38 | |||
| 10/28/2017 | SE Missouri State | 7 | at | Jacksonville State (10-2,8-0) | 23 | |||
| 11/4/2017 | Tennessee-Martin (6-5,4-4) | 16 | at | SE Missouri State | 14 | |||
| 11/11/2017 | SE Missouri State | 20 | at | Tennessee State (6-5,2-5) | 23 | |||
| 11/18/2017 | Murray State (3-8,2-5) | 10 | at | SE Missouri State | 21 |
| vs SE Missouri State | vs Other Opponents | SE Missouri State compared to OOs | |
| Record: | 8-3 | 46-67 | |
| Points Scored: | 21.82 | 22.19 | 0.37 |
| Points Allowed: | 20.45 | 25.58 | -5.13 |
| Margin: | 1.37 | -3.39 | -4.76 |
| Total Points: | 42.27 | 47.77 | -5.50 |