| 9/2/2017 | Wyoming (8-5) | 3 | at | Iowa | 24 | MW | ||
| 9/9/2017 | Iowa | 44 | at | Iowa State (8-5) | 41 | OT | at B12 | |
| 9/16/2017 | North Texas (9-5) | 14 | at | Iowa | 31 | CUSA | ||
| 9/23/2017 | Penn State (11-2,7-2) | 21 | at | Iowa | 19 | |||
| 9/30/2017 | Iowa | 10 | at | Michigan State (10-3,7-2) | 17 | |||
| 10/7/2017 | Illinois (2-10,0-9) | 16 | at | Iowa | 45 | |||
| 10/21/2017 | Iowa | 10 | at | Northwestern (10-3,7-2) | 17 | |||
| 10/28/2017 | Minnesota (5-7,2-7) | 10 | at | Iowa | 17 | |||
| 11/4/2017 | Ohio State (12-2,9-1) | 24 | at | Iowa | 55 | |||
| 11/11/2017 | Iowa | 14 | at | Wisconsin (13-1,9-1) | 38 | |||
| 11/18/2017 | Purdue (7-6,4-5) | 24 | at | Iowa | 15 | |||
| 11/24/2017 | Iowa | 56 | at | Nebraska (4-8,3-6) | 14 | |||
| 12/27/2017 | Iowa | 27 | vs | Boston College (7-6) | 20 | Pinstripe Bowl (New York NY) | vs ACC |
| vs Iowa | vs Other Opponents | Iowa compared to OOs | |
| Record: | 5-8 | 101-55 | |
| Points Scored: | 19.92 | 29.65 | 9.73 |
| Points Allowed: | 28.23 | 22.26 | 5.97 |
| Margin: | -8.31 | 7.39 | 15.70 |
| Total Points: | 48.15 | 51.91 | -3.76 |