| 9/2/2021 | West Virginia Wesleyan | 3 | at | Drake | 45 | MtnE (D2) | ||
| 9/4/2021 | Robert Morris | vs | Dayton | Canceled COVID | vs BigS | |||
| Marist | vs | Georgetown | Canceled COVID | vs Pat | ||||
| Butler | 7 | at | Illinois State | 49 | @ MVC | |||
| Valparaiso | 10 | at | Indiana Wesleyan | 28 | @ MSFA (NAIA) | |||
| Morehead State | 10 | at | James Madison | 68 | @ CAAF | |||
| St Andrews | 43 | at | Presbyterian | 84 | MSC (NAIA) | |||
| Cal Poly | 28 | at | San Diego | 17 | BSky | |||
| St Francis IL | vs | St Thomas | Canceled COVID | vs MSFA (NAIA) | ||||
| Warner U. | 14 | at | Stetson | 54 | MSC (NAIA) | |||
| Davidson | 24 | at | VMI | 45 | @ SoCon | |||
| 9/11/2021 | DePauw | 24 | at | Butler | 49 | NCA (D3) | ||
| Shaw | 26 | at | Davidson | 28 | CIAA (D2) | |||
| Eastern Illinois | 10 | at | Dayton | 17 | OVC | |||
| St Thomas | 12 | at | Michigan Tech | 9 | @ GLIAC (D2) | |||
| Drake | 7 | at | Montana State | 45 | @ BSky | |||
| Point | 9 | at | Morehead State | 62 | MSC (NAIA) | |||
| Valparaiso | 0 | at | North Dakota State | 64 | @ MVC | |||
| Fort Lauderdale | 3 | at | Presbyterian | 68 | None (Unk?) | |||
| UC Davis | 53 | at | San Diego | 7 | BSky | |||
| Ave Maria | 16 | at | Stetson | 49 | MSC (NAIA) | |||
| 9/18/2021 | Morehead State | 35 | at | Austin Peay | 59 | @ OVC | ||
| Presbyterian | 0 | at | Campbell | 72 | @ BigS | |||
| Marist | 14 | at | Columbia | 37 | @ Ivy | |||
| San Diego | 10 | at | Montana State | 52 | @ BSky | |||
| Drake | 0 | at | North Dakota | 38 | @ MVC | |||
| St Thomas | 3 | at | Northern Iowa | 44 | @ MVC | |||
| Dayton | 3 | at | Southern Illinois | 55 | @ MVC | |||
| Butler | 77 | at | Taylor | 24 | @ MSFA (NAIA) | |||
| Dartmouth | 28 | at | Valparaiso | 18 | Ivy | |||
| 9/25/2021 | San Diego | 16 | at | Davidson | 28 | |||
| Presbyterian | 43 | at | Dayton | 63 | ||||
| Valparaiso | 24 | at | Drake | 21 | ||||
| Bryant | 34 | at | Marist | 17 | NE | |||
| Stetson | 0 | at | Princeton | 63 | @ Ivy | |||
| Butler | 0 | at | St Thomas | 36 | ||||
| 10/2/2021 | Drake | 6 | at | Butler | 3 | |||
| Dayton | 38 | at | Morehead State | 45 | OT | |||
| St Thomas | 24 | at | San Diego | 27 | ||||
| Davidson | 35 | at | Stetson | 28 | ||||
| Marist | 27 | at | Valparaiso | 24 | OT | |||
| 10/9/2021 | San Diego | 52 | at | Butler | 21 | |||
| Dayton | 28 | at | Drake | 10 | ||||
| Stetson | 3 | at | Marist | 34 | ||||
| Morehead State | 38 | at | Presbyterian | 30 | ||||
| Valparaiso | 13 | at | St Thomas | 20 | ||||
| 10/16/2021 | Presbyterian | 35 | at | Davidson | 70 | |||
| Marist | 20 | at | Dayton | 17 | ||||
| Butler | 8 | at | Morehead State | 31 | ||||
| Drake | 10 | at | San Diego | 13 | ||||
| St Thomas | 38 | at | Stetson | 7 | ||||
| 10/23/2021 | Davidson | 49 | at | Butler | 35 | |||
| Stetson | vs | Drake | Cancelled COVID | |||||
| Morehead State | 27 | at | Marist | 24 | ||||
| San Diego | 69 | at | Presbyterian | 28 | ||||
| Dayton | 28 | at | Valparaiso | 45 | ||||
| 10/30/2021 | Butler | 31 | at | Dayton | 38 | |||
| Davidson | 29 | at | Morehead State | 22 | ||||
| Stetson | 56 | at | Presbyterian | 14 | ||||
| Valparaiso | 14 | at | San Diego | 21 | ||||
| Marist | 7 | at | St Thomas | 27 | ||||
| 11/6/2021 | St Thomas | 15 | at | Davidson | 42 | |||
| Drake | 0 | at | Marist | 7 | ||||
| Morehead State | 3 | at | San Diego | 10 | ||||
| Dayton | 41 | at | Stetson | 13 | ||||
| Presbyterian | 55 | at | Valparaiso | 65 | ||||
| 11/13/2021 | Valparaiso | 47 | at | Butler | 3 | |||
| Davidson | 29 | at | Dayton | 38 | ||||
| St Thomas | 21 | at | Drake | 14 | ||||
| Stetson | 35 | at | Morehead State | 36 | ||||
| Marist | 57 | at | Presbyterian | 32 | ||||
| 11/20/2021 | Drake | 14 | at | Davidson | 45 | |||
| Butler | 28 | at | Marist | 21 | ||||
| Presbyterian | 15 | at | St Thomas | 54 | ||||
| San Diego | 41 | at | Stetson | 16 | ||||
| Morehead State | 51 | at | Valparaiso | 38 | ||||
| 11/27/2021 | Davidson | 21 | at | Kennesaw St | 48 | @ BigS |