| 9/2/2021 | West Virginia Wesleyan | 3 | at | Drake (2-8) | 45 | at Pio | ||
| 9/18/2021 | West Virginia Wesleyan | 25 | at | Concord (4-6,4-6) | 28 | |||
| 9/25/2021 | West Liberty (4-7,4-6) | 31 | at | West Virginia Wesleyan | 0 | |||
| 10/2/2021 | West Virginia Wesleyan | 0 | at | Wheeling (5-6,5-5) | 38 | |||
| 10/9/2021 | West Virginia State (6-5,6-4) | 38 | at | West Virginia Wesleyan | 3 | |||
| 10/16/2021 | West Virginia Wesleyan | 14 | at | Notre Dame OH (11-2,9-1) | 52 | |||
| 10/23/2021 | Alderson-Broaddus (1-10,1-9) | 49 | at | West Virginia Wesleyan | 20 | |||
| 10/28/2021 | West Virginia Wesleyan | 6 | at | Charleston WV (8-2,8-2) | 45 | |||
| 11/6/2021 | West Virginia Wesleyan | 14 | at | Frostburg State (10-1,9-1) | 55 | |||
| 11/13/2021 | Glenville State (3-7,3-7) | 43 | at | West Virginia Wesleyan | 13 |
| vs West Virginia Wesleyan | vs Other Opponents | West Virginia Wesleyan compared to OOs | |
| Record: | 10-0 | 44-54 | |
| Points Scored: | 42.40 | 24.00 | -18.40 |
| Points Allowed: | 9.80 | 24.72 | -14.92 |
| Margin: | 32.60 | -0.72 | -33.32 |
| Total Points: | 52.20 | 48.72 | 3.48 |