| 9/4/2021 | Albany NY (2-9) | 6 | at | North Dakota State | 28 | CAAF | ||
| 9/11/2021 | Valparaiso (4-7) | 0 | at | North Dakota State | 64 | Pio | ||
| 9/18/2021 | North Dakota State | 35 | at | Towson (4-7) | 7 | at CAAF | ||
| 10/2/2021 | North Dakota State | 16 | at | North Dakota (5-6,3-5) | 10 | |||
| 10/9/2021 | Northern Iowa (6-6,4-4) | 20 | at | North Dakota State | 34 | |||
| 10/16/2021 | North Dakota State | 20 | at | Illinois State (4-7,2-6) | 0 | |||
| 10/23/2021 | Missouri State (8-4,6-2) | 20 | at | North Dakota State | 27 | |||
| 10/30/2021 | Indiana State (5-6,3-5) | 2 | at | North Dakota State | 44 | |||
| 11/6/2021 | North Dakota State | 19 | at | South Dakota State (11-4,5-3) | 27 | |||
| 11/13/2021 | North Dakota State | 49 | at | Youngstown State (3-7,2-6) | 17 | |||
| 11/20/2021 | South Dakota (7-5,5-4) | 24 | at | North Dakota State | 52 | |||
| 12/4/2021 | Southern Illinois (8-5,6-4) | 7 | at | North Dakota State | 38 | |||
| 12/11/2021 | East Tennessee St (11-2) | 3 | at | North Dakota State | 27 | FCS quarterfinals | SoCon | |
| 12/17/2021 | James Madison (12-2) | 14 | at | North Dakota State | 20 | FCS semifinal | CAAF | |
| 1/8/2022 | Montana State (12-3) | 10 | vs | North Dakota State | 38 | FCS Championship - Frisco TX | BSky |
| vs North Dakota State | vs Other Opponents | North Dakota State compared to OOs | |
| Record: | 1-14 | 101-66 | |
| Points Scored: | 11.13 | 28.84 | 17.71 |
| Points Allowed: | 34.07 | 22.38 | 11.69 |
| Margin: | -22.94 | 6.46 | 29.40 |
| Total Points: | 45.20 | 51.22 | -6.02 |