| 9/4/2021 | Northern Iowa | 10 | at | Iowa State (7-6) | 16 | at B12 | ||
| 9/11/2021 | Northern Iowa | 34 | at | Sacramento State (9-3) | 16 | at BSky | ||
| 9/18/2021 | St Thomas (7-3) | 3 | at | Northern Iowa | 44 | Pio | ||
| 10/2/2021 | Youngstown State (3-7,2-6) | 7 | at | Northern Iowa | 34 | |||
| 10/9/2021 | Northern Iowa | 20 | at | North Dakota State (14-1,8-1) | 34 | |||
| 10/16/2021 | South Dakota (7-5,5-4) | 34 | at | Northern Iowa | 21 | |||
| 10/23/2021 | Northern Iowa | 26 | at | South Dakota State (11-4,5-3) | 17 | |||
| 10/30/2021 | Southern Illinois (8-5,6-4) | 16 | at | Northern Iowa | 23 | |||
| 11/6/2021 | Northern Iowa | 10 | at | Illinois State (4-7,2-6) | 17 | OT | ||
| 11/13/2021 | Northern Iowa | 27 | at | Missouri State (8-4,6-2) | 34 | |||
| 11/20/2021 | Western Illinois (2-9,2-6) | 3 | at | Northern Iowa | 41 | |||
| 11/27/2021 | Northern Iowa | 9 | at | Eastern Washington (10-3) | 19 | at BSky |
| vs Northern Iowa | vs Other Opponents | Northern Iowa compared to OOs | |
| Record: | 6-6 | 84-51 | |
| Points Scored: | 18.00 | 31.73 | 13.73 |
| Points Allowed: | 24.92 | 23.15 | 1.77 |
| Margin: | -6.92 | 8.58 | 15.50 |
| Total Points: | 42.92 | 54.88 | -11.96 |