| 9/4/2021 | Valparaiso (4-7) | 10 | at | Indiana Wesleyan | 28 | Pio (1AA) | ||
| 9/11/2021 | Indiana Wesleyan | at | Trinity International (3-6,1-6) | Forfeit | ||||
| 9/18/2021 | Olivet Nazarene (7-3,7-3) | 28 | at | Indiana Wesleyan | 52 | |||
| 10/2/2021 | Indiana Wesleyan | 21 | at | Concordia MI (9-2,9-1) | 28 | |||
| 10/9/2021 | Marian IN (9-3,8-1) | 7 | at | Indiana Wesleyan | 41 | |||
| 10/16/2021 | Lawrence Tech (5-3,4-3) | 0 | at | Indiana Wesleyan | 35 | |||
| 10/23/2021 | Indiana Wesleyan | 23 | at | St Francis IN (3-6,3-6) | 21 | |||
| 10/30/2021 | Siena Heights (4-5,4-5) | 10 | at | Indiana Wesleyan | 27 | |||
| 11/6/2021 | Indiana Wesleyan | 61 | at | Taylor (2-8,2-7) | 0 | |||
| 11/13/2021 | Indiana Wesleyan | at | Madonna (0-8,0-8) | Forfeit | ||||
| 11/20/2021 | Kansas Wesleyan (10-2) | at | Indiana Wesleyan | Forfeit | KCAC |
| vs Indiana Wesleyan | vs Other Opponents | Indiana Wesleyan compared to OOs | |
| Record: | 1-7 | 55-46 | |
| Points Scored: | 13.00 | 28.56 | 15.56 |
| Points Allowed: | 36.00 | 26.62 | 9.38 |
| Margin: | -23.00 | 1.94 | 24.94 |
| Total Points: | 49.00 | 55.18 | -6.18 |