| 9/4/2021 | North Dakota | 35 | at | Idaho State (1-10) | 14 | at BSky | ||
| 9/10/2021 | North Dakota | 24 | at | Utah State (11-3) | 48 | at MW | ||
| 9/18/2021 | Drake (2-8) | 0 | at | North Dakota | 38 | Pio | ||
| 10/2/2021 | North Dakota State (14-1,8-1) | 16 | at | North Dakota | 10 | |||
| 10/9/2021 | North Dakota | 13 | at | South Dakota (7-5,5-4) | 20 | |||
| 10/16/2021 | North Dakota | 28 | at | Southern Illinois (8-5,6-4) | 31 | |||
| 10/23/2021 | Western Illinois (2-9,2-6) | 10 | at | North Dakota | 34 | |||
| 10/30/2021 | North Dakota | 28 | at | Missouri State (8-4,6-2) | 32 | |||
| 11/6/2021 | Youngstown State (3-7,2-6) | 21 | at | North Dakota | 24 | |||
| 11/13/2021 | Illinois State (4-7,2-6) | 7 | at | North Dakota | 14 | |||
| 11/20/2021 | North Dakota | 21 | at | South Dakota State (11-4,5-3) | 24 |
| vs North Dakota | vs Other Opponents | North Dakota compared to OOs | |
| Record: | 6-5 | 65-58 | |
| Points Scored: | 20.27 | 27.93 | 7.66 |
| Points Allowed: | 24.45 | 24.90 | -0.45 |
| Margin: | -4.18 | 3.03 | 7.21 |
| Total Points: | 44.72 | 52.83 | -8.11 |