| 9/4/2021 | St Francis IL | vs | St Thomas (7-3) | Canceled COVID | vs Pio | |||
| 9/18/2021 | Marian IN (9-3,8-1) | 40 | at | St Francis IL | 17 | |||
| 9/25/2021 | St Francis IL | 8 | at | Siena Heights (4-5,4-5) | 13 | |||
| 10/2/2021 | Missouri Baptist (4-7,2-7) | 13 | at | St Francis IL | 20 | |||
| 10/9/2021 | St Francis IL | 42 | at | Trinity International (3-6,1-6) | 21 | |||
| 10/16/2021 | Judson (4-7,4-6) | 0 | at | St Francis IL | 34 | |||
| 10/23/2021 | St Francis IL | 35 | at | Saint Ambrose (4-7,3-6) | 14 | |||
| 10/30/2021 | Olivet Nazarene (7-3,7-3) | 30 | at | St Francis IL | 43 | |||
| 11/6/2021 | St Francis IL | 14 | at | Roosevelt (4-4,3-4) | 0 | |||
| 11/13/2021 | St Xavier (7-3,7-2) | 26 | at | St Francis IL | 20 | OT |
| vs St Francis IL | vs Other Opponents | St Francis IL compared to OOs | |
| Record: | 3-6 | 50-42 | |
| Points Scored: | 17.44 | 27.75 | 10.31 |
| Points Allowed: | 25.89 | 23.95 | 1.94 |
| Margin: | -8.45 | 3.80 | 12.25 |
| Total Points: | 43.33 | 51.70 | -8.37 |